Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Alcohol (ethanol [EtOH]) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the United States. The etiology of FAS/FASD remains poorly understood. This review focuses on the effects of prenatal alcohol exposure (PAE) on fetal cerebrovascular function. A brief introduction to the epidemiology of alcohol consumption and the developmental characteristics of fetal cerebral circulation is followed by several sections that discuss current evidence documenting alcohol-driven alterations of fetal cerebral blood flow, artery function, and microvessel networks. The material offers mechanistic insights at the vascular level itself into the pathophysiology of PAE.

Original languageEnglish (US)
Pages (from-to)1006-1018
Number of pages13
JournalAlcoholism: Clinical and Experimental Research
Volume42
Issue number6
DOIs
StatePublished - Jun 1 2018

Fingerprint

Cerebrovascular Circulation
Fetal Alcohol Spectrum Disorders
Alcohol Drinking
Alcohols
Mothers
Microvessels
Fetal Blood
Blood Vessels
Epidemiology
Ethanol
Arteries
Pregnancy

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption. / Bukiya, Anna; Dopico, Alejandro.

In: Alcoholism: Clinical and Experimental Research, Vol. 42, No. 6, 01.06.2018, p. 1006-1018.

Research output: Contribution to journalReview article

@article{7957d4ae100d4566a5808aa7517abeea,
title = "Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption",
abstract = "Alcohol (ethanol [EtOH]) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the United States. The etiology of FAS/FASD remains poorly understood. This review focuses on the effects of prenatal alcohol exposure (PAE) on fetal cerebrovascular function. A brief introduction to the epidemiology of alcohol consumption and the developmental characteristics of fetal cerebral circulation is followed by several sections that discuss current evidence documenting alcohol-driven alterations of fetal cerebral blood flow, artery function, and microvessel networks. The material offers mechanistic insights at the vascular level itself into the pathophysiology of PAE.",
author = "Anna Bukiya and Alejandro Dopico",
year = "2018",
month = "6",
day = "1",
doi = "10.1111/acer.13755",
language = "English (US)",
volume = "42",
pages = "1006--1018",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Fetal Cerebral Circulation as Target of Maternal Alcohol Consumption

AU - Bukiya, Anna

AU - Dopico, Alejandro

PY - 2018/6/1

Y1 - 2018/6/1

N2 - Alcohol (ethanol [EtOH]) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the United States. The etiology of FAS/FASD remains poorly understood. This review focuses on the effects of prenatal alcohol exposure (PAE) on fetal cerebrovascular function. A brief introduction to the epidemiology of alcohol consumption and the developmental characteristics of fetal cerebral circulation is followed by several sections that discuss current evidence documenting alcohol-driven alterations of fetal cerebral blood flow, artery function, and microvessel networks. The material offers mechanistic insights at the vascular level itself into the pathophysiology of PAE.

AB - Alcohol (ethanol [EtOH]) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the United States. The etiology of FAS/FASD remains poorly understood. This review focuses on the effects of prenatal alcohol exposure (PAE) on fetal cerebrovascular function. A brief introduction to the epidemiology of alcohol consumption and the developmental characteristics of fetal cerebral circulation is followed by several sections that discuss current evidence documenting alcohol-driven alterations of fetal cerebral blood flow, artery function, and microvessel networks. The material offers mechanistic insights at the vascular level itself into the pathophysiology of PAE.

UR - http://www.scopus.com/inward/record.url?scp=85046670627&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85046670627&partnerID=8YFLogxK

U2 - 10.1111/acer.13755

DO - 10.1111/acer.13755

M3 - Review article

VL - 42

SP - 1006

EP - 1018

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 6

ER -