Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling

Lee P. Shulman, Carole M. Meyers, Joe Leigh Simpson, Richard N. Andersen, Elizabeth Tolley, Sherman Elias

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Transcervical and transabdominal chorionic villus sampling are believed, on the basis of indirect evidence, to result in fetomaternal transfusion. We sought to measure this phenomenon by devising a simple method that would allow us to identify variables that influence fetomaternal transfusion. We investigated patients undergoing transcervical-chorionic villus sampling (n = 15) and transabdominal-chorionic villus sampling (n = 15), restricting the sample to subjects who required only a single catheter passage or needle insertion to obtain villi. Maternal serum α-fetoprotein was measured before and after the procedure along with α-fetoprotein concentration of the transport medium into which the villi had been aspirated. We first confirmed that the change in maternal serum α-fetoprotein levels after chorionic villus sampling, an indirect measure of fetomaternal transfusion, was indeed correlated with the α-fetoprotein concentration of transport medium into which the villi were aspirated (p = 0.0350). Fetomaternal transfusion next proved to be correlated with the amount of villi obtained (p = 0.0279). However, when adjusted for the amount of villi obtained, no significant difference was observed between transcervical and transabdominal-chorionic villus sampling with respect to the change in maternal serum α-fetoprotein levels after chorionic villus sampling (p = 0.8512). These data suggest that the magnitude of fetomaternal transfusion depends on the amount of villi obtained but not on the chorionic villus sampling method used.

Original languageEnglish (US)
Pages (from-to)1185-1188
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume162
Issue number5
DOIs
StatePublished - Jan 1 1990

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Fetomaternal Transfusion
Chorionic Villi Sampling
Chorionic Villi
Fetal Proteins
Mothers
Serum
Needles
Catheters

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling. / Shulman, Lee P.; Meyers, Carole M.; Simpson, Joe Leigh; Andersen, Richard N.; Tolley, Elizabeth; Elias, Sherman.

In: American Journal of Obstetrics and Gynecology, Vol. 162, No. 5, 01.01.1990, p. 1185-1188.

Research output: Contribution to journalArticle

Shulman, Lee P. ; Meyers, Carole M. ; Simpson, Joe Leigh ; Andersen, Richard N. ; Tolley, Elizabeth ; Elias, Sherman. / Fetomaternal transfusion depends on amount of chorionic villi aspirated but not on method of chorionic villus sampling. In: American Journal of Obstetrics and Gynecology. 1990 ; Vol. 162, No. 5. pp. 1185-1188.
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