Fetuin-A and BMD in older persons

The health aging and body composition (Health ABC) study

Joachim H. Ix, Christina L. Wassel, Douglas C. Bauer, Damon Toroian, Frances Tylavsky, Jane A. Cauley, Tamara B. Harris, Paul A. Price, Steven R. Cummings, Michael G. Shlipak

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Fetuin-A is a hepatic secretory protein that promotes bone mineralization in vitro. Whether fetuin-A levels are associated with BMD in humans is unknown. The Health Aging and Body Composition study enrolled 3075 well-functioning black and white persons 70-79 yr of age and measured BMD. This cross-sectional study measured serum fetuin-A using ELISA among a random sample of 508 participants within sex and race strata. Multivariate linear regression analysis evaluated the associations of fetuin-A with BMD. Among women (n = 257), higher fetuin-A levels were significantly associated with higher total hip (p = 0.02), lumbar spine (p = 0.03), and whole body BMD (p = 0.01) in models adjusted for age, race, diabetes, alcohol and tobacco use, physical activity, body mass index, C-reactive protein levels, calcium supplement, and estrogen use. For example, each SD (0.38 g/liter) higher level of fetuin-A was associated with 0.016 g/cm2 higher total hip areal BMD. The association was of similar magnitude and direction for femoral neck BMD but did not reach statistical significance (p = 0.11). In contrast, among men (n = 251), fetuin-A had no significant associations with total hip (p = 0.79), lumbar spine (p = 0.35), whole body (p = 0.46), or femoral neck BMD (p = 0.54) in multivariable models. We conclude that higher fetuin-A levels are independently associated with higher BMD among well-functioning community-dwelling older women but not older men.Future studies should evaluate whether fetuin-A may refine fracture risk assessment in older women.

Original languageEnglish (US)
Pages (from-to)514-521
Number of pages8
JournalJournal of Bone and Mineral Research
Volume24
Issue number3
DOIs
StatePublished - Mar 1 2009

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alpha-2-HS-Glycoprotein
Body Composition
Health
Hip
Femur Neck
Spine
Independent Living
Physiologic Calcification
Tobacco Use
C-Reactive Protein
Linear Models
Estrogens
Body Mass Index
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Regression Analysis
Alcohols
Exercise

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

Cite this

Fetuin-A and BMD in older persons : The health aging and body composition (Health ABC) study. / Ix, Joachim H.; Wassel, Christina L.; Bauer, Douglas C.; Toroian, Damon; Tylavsky, Frances; Cauley, Jane A.; Harris, Tamara B.; Price, Paul A.; Cummings, Steven R.; Shlipak, Michael G.

In: Journal of Bone and Mineral Research, Vol. 24, No. 3, 01.03.2009, p. 514-521.

Research output: Contribution to journalArticle

Ix, JH, Wassel, CL, Bauer, DC, Toroian, D, Tylavsky, F, Cauley, JA, Harris, TB, Price, PA, Cummings, SR & Shlipak, MG 2009, 'Fetuin-A and BMD in older persons: The health aging and body composition (Health ABC) study', Journal of Bone and Mineral Research, vol. 24, no. 3, pp. 514-521. https://doi.org/10.1359/jbmr.081017
Ix, Joachim H. ; Wassel, Christina L. ; Bauer, Douglas C. ; Toroian, Damon ; Tylavsky, Frances ; Cauley, Jane A. ; Harris, Tamara B. ; Price, Paul A. ; Cummings, Steven R. ; Shlipak, Michael G. / Fetuin-A and BMD in older persons : The health aging and body composition (Health ABC) study. In: Journal of Bone and Mineral Research. 2009 ; Vol. 24, No. 3. pp. 514-521.
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