FGF23 e cuore

Translated title of the contribution: FGF23 and the heart

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The prevalence of chronic kidney disease (CKD) has now reached epidemic proportions and it is very likely that it will continue to rise with the increasing prevalence of juvenile diabetes mellitus, hypertension and aging population. CKD is a risk factor for cardiovascular disease (CVD) and cardiovascular disease can lead to CKD. It is also well known that patients with CKD have a higher risk of death from CVD than of progressing to end-stage renal disease that requires renal replacement therapy. In patients with CKD, there is a higher mortality from sudden cardiac death and congestive heart failure than coronary artery disease, which is not the case in the general population. The high prevalence of congestive heart failure in CKD is due to cardiac remodeling which progresses from concentric remodeling to concentric and eccentric hypertrophy, leading to left ventricular hypertrophy with both systolic and diastolic dysfunction. Recent studies have suggested that, in patients with chronic kidney disease, common traditional risk factors for cardiovascular disease such as hypertension, hyperlipidemia and obesity may not be the main determinants of cardiovascular disease. Among the various non-traditional cardiovascular risk factors present in patients with chronic kidney disease, abnormalities of CKD related mineral and bone disorder, which includes elevated fibroblast growth factor 23 (FGF23) have been one of the most extensively studied. However, after many years of research, the debate over the exact pathways by which FGF23 may lead to increased CVD still continues. FGF23 may have both direct and indirect effects on the cardiovascular system. Better understanding of the most relevant pathophysiologic pathways for FGF23 may lead to therapeutic interventions against cardiovascular disease in patients with CKD.

Original languageItalian
JournalGiornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia
Volume31
Issue number6
StatePublished - Nov 1 2014

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Chronic Renal Insufficiency
Cardiovascular Diseases
Heart Failure
Hypertension
Chronic Kidney Disease-Mineral and Bone Disorder
fibroblast growth factor 23
Renal Replacement Therapy
Sudden Cardiac Death
Left Ventricular Hypertrophy
Cardiovascular System
Hyperlipidemias
Hypertrophy
Population
Chronic Kidney Failure
Coronary Artery Disease
Diabetes Mellitus
Obesity
Mortality
Research

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

FGF23 e cuore. / Ezumba, I.; Quarles, Leigh; Kovesdy, Csaba.

In: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia, Vol. 31, No. 6, 01.11.2014.

Research output: Contribution to journalReview article

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