Fiber optic microendoscopy for preclinical study of bacterial infection dynamics

Nooman Mufti, Ying Kong, Jeffrey D. Cirillo, Kristen C. Maitland

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 μm resolution, a 750 μm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively.

Original languageEnglish (US)
Pages (from-to)1121-1134
Number of pages14
JournalBiomedical Optics Express
Volume2
Issue number5
DOIs
StatePublished - May 1 2011

Fingerprint

infectious diseases
Mycobacterium bovis
Bacterial Infections
Bacillus
fiber optics
Stem Cells
Animal Models
Fluorescence
inoculum
Bacteria
Lung
Skin
animal models
Infection
lungs
bacteria
bundles
field of view
fluorescence
fibers

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics

Cite this

Fiber optic microendoscopy for preclinical study of bacterial infection dynamics. / Mufti, Nooman; Kong, Ying; Cirillo, Jeffrey D.; Maitland, Kristen C.

In: Biomedical Optics Express, Vol. 2, No. 5, 01.05.2011, p. 1121-1134.

Research output: Contribution to journalArticle

Mufti, Nooman ; Kong, Ying ; Cirillo, Jeffrey D. ; Maitland, Kristen C. / Fiber optic microendoscopy for preclinical study of bacterial infection dynamics. In: Biomedical Optics Express. 2011 ; Vol. 2, No. 5. pp. 1121-1134.
@article{e019b98682d942498f77de5d46425c9b,
title = "Fiber optic microendoscopy for preclinical study of bacterial infection dynamics",
abstract = "We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 μm resolution, a 750 μm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Gu{\'e}rin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively.",
author = "Nooman Mufti and Ying Kong and Cirillo, {Jeffrey D.} and Maitland, {Kristen C.}",
year = "2011",
month = "5",
day = "1",
doi = "10.1364/BOE.2.001121",
language = "English (US)",
volume = "2",
pages = "1121--1134",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "5",

}

TY - JOUR

T1 - Fiber optic microendoscopy for preclinical study of bacterial infection dynamics

AU - Mufti, Nooman

AU - Kong, Ying

AU - Cirillo, Jeffrey D.

AU - Maitland, Kristen C.

PY - 2011/5/1

Y1 - 2011/5/1

N2 - We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 μm resolution, a 750 μm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively.

AB - We explore the use of fiber optic microendoscopy to image and quantify bacterial infection in the skin and lungs using an animal model. The contact probe fiber bundle fluorescence microendoscope has a 4 μm resolution, a 750 μm field of view, and a 1 mm outer diameter. Subcutaneous and intra-tracheal infections of fluorescent Mycobacterium bovis Bacillus Calmette-Guérin (BCG) bacteria were detected in situ from inocula down to 104 and 107 colony forming units, respectively.

UR - http://www.scopus.com/inward/record.url?scp=79960808848&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960808848&partnerID=8YFLogxK

U2 - 10.1364/BOE.2.001121

DO - 10.1364/BOE.2.001121

M3 - Article

VL - 2

SP - 1121

EP - 1134

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 5

ER -