Fibrinolysis in multisystem trauma patients

Blaine Enderson, James Chen, Richard Robinson, Kimball I. Maull

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Changes in the fibrinolytic system may lead to coagulation disorders in acute trauma patients. This study examined fibrin degradation by measuring D-dimer crosslinked fibrin degradation products (indicates hypercoagulability), plasminogen activators (fibrinolysis), and antithrombin III in 42 adult trauma patients and correlated these data with injury severity, types of injury, complications, and clinical tests of coagulation. Hypercoagulability and suppression of fibrinolysis were seen in most patients and were not correlated with severity of injury. These changes appeared most severe in patients with nervous system injury. Several patients with less severe injuries but evidence of hypercoagulability developed clinical evidence of pathologic thrombosis. Latex agglutination of D-dimer provides a rapid test of fibrinolysis that may be clinically useful in the management of trauma patients who cannot be easily studied for thrombosis.

Original languageEnglish (US)
Pages (from-to)1240-1246
Number of pages7
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume31
Issue number9
DOIs
StatePublished - Jan 1 1991

Fingerprint

Fibrinolysis
Wounds and Injuries
Thrombophilia
Thrombosis
Nervous System Trauma
Fibrin Fibrinogen Degradation Products
Antithrombin III
Plasminogen Activators
Agglutination
Latex
Fibrin

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Fibrinolysis in multisystem trauma patients. / Enderson, Blaine; Chen, James; Robinson, Richard; Maull, Kimball I.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 31, No. 9, 01.01.1991, p. 1240-1246.

Research output: Contribution to journalArticle

Enderson, Blaine ; Chen, James ; Robinson, Richard ; Maull, Kimball I. / Fibrinolysis in multisystem trauma patients. In: Journal of Trauma - Injury, Infection and Critical Care. 1991 ; Vol. 31, No. 9. pp. 1240-1246.
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