Fibroblast growth factor 23

uremic toxin or innocent bystander in chronic kidney disease?

Jason R. Stubbs, Leigh Quarles

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Our understanding of the role of FGF23 in CKD continues to rapidly advance. Information regarding the onset of FGF23 elevations in relationship to changes in parathyroid gland function, renal production of 1,25(OH)2D, and phosphate excretion may provide clues to its role in the adaptive changes in mineral homeostasis that occur during progressive kidney diseases. More knowledge of the regulation and function of FGF23 in CKD will likely improve our understanding of the pathogenesis of disordered mineral metabolism, lead to changes in the medical management of this disorder, and establish additional biological links between disorders of mineral metabolism and associated comorbidities in patients with progressive renal failure.

Original languageEnglish (US)
JournalNephrology news & issues
Volume23
Issue number6
StatePublished - May 2009
Externally publishedYes

Fingerprint

Chronic Renal Insufficiency
Minerals
Parathyroid Glands
Kidney Diseases
Renal Insufficiency
Comorbidity
Homeostasis
Phosphates
Kidney
fibroblast growth factor 23

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Fibroblast growth factor 23 : uremic toxin or innocent bystander in chronic kidney disease? / Stubbs, Jason R.; Quarles, Leigh.

In: Nephrology news & issues, Vol. 23, No. 6, 05.2009.

Research output: Contribution to journalReview article

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