Fibrosis of the human heart and systemic organs in adrenal adenoma

Scott E. Campbell, Alberto A. Diaz-Arias, Karl Weber

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

In experimental animals, chronic mineralocorticoid (MC) excess is associated with fibrosis of the myocardium and systemic organs, where both a reactive, i.e. interstitial and perivascular, and reparative, i.e. microscopic scarring following cardiac myocyte necrosis, fibrosis are found. We sought to determine if a similar fibrous tissue response was present in human myocardium and systemic organs in association with adrenal adenoma. Postmortem specimens of heart, adrenals, pancreas, lungs, kidney and liver were obtained from 5 patients (age 67 ± 5 years) with autopsy-proven adrenal adenoma. Documented histologically normal tissue from age-matched patients was used for comparison. Tissue sections were stained with the collagen specific stain Sirius Red F3BA and analyzed using normal and polarized light. Reactive and/or reparative fibrosis was found in the heart, pancreas, adrenal glands and lungs, but not in the kidney or liver. These observations support a link between chronic MC excess and fibrosis of the heart and systemic organs in humans with adrenal adenoma.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalBlood Pressure
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1992

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Adenoma
Fibrosis
Mineralocorticoids
Pancreas
Myocardium
Kidney
Lung
Liver
Adrenal Glands
Cardiac Myocytes
Cicatrix
Autopsy
Necrosis
Coloring Agents
Collagen
Light

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Fibrosis of the human heart and systemic organs in adrenal adenoma. / Campbell, Scott E.; Diaz-Arias, Alberto A.; Weber, Karl.

In: Blood Pressure, Vol. 1, No. 3, 01.01.1992, p. 149-156.

Research output: Contribution to journalArticle

Campbell, Scott E. ; Diaz-Arias, Alberto A. ; Weber, Karl. / Fibrosis of the human heart and systemic organs in adrenal adenoma. In: Blood Pressure. 1992 ; Vol. 1, No. 3. pp. 149-156.
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