Finding chromosome centromeres using band pattern information

Jens Gregor, Erik Granum

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

A method for finding centromeres of chromosomes using band pattern information only is described. Rather than using shape-related characteristics to identify the position of the centromere constriction, its position in relation to the band patern is encoded into a structural band pattern model for each chromosome type individually. These models are automatically inferred from strings of symbols representing band pattern profiles. When used for analysis, a sample string is compared with a model from which the position in the string corresponding to the centromere can be derived. The approach is experimentally investigated with centromere finding both for class of the chromosomes known and unknown. A scheme for simultaneous centromere finding and classification is also proposed and tested on different band pattern representations with encouraging results.

Original languageEnglish (US)
Pages (from-to)55-67
Number of pages13
JournalComputers in Biology and Medicine
Volume21
Issue number1-2
DOIs
StatePublished - Jan 1 1991

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Centromere
Chromosomes
Constriction

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Health Informatics

Cite this

Finding chromosome centromeres using band pattern information. / Gregor, Jens; Granum, Erik.

In: Computers in Biology and Medicine, Vol. 21, No. 1-2, 01.01.1991, p. 55-67.

Research output: Contribution to journalArticle

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