Findings in normal rats following administration of gliadorphin-7 (GD-7)

Zhongjie Sun, Robert Cade

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of β-casomorphin-7 (βC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow GD-7 400μg and βC-7 30μg/kg BW. GD-7 affects only these three regions while βC-7affects 45. FLI is prevented by Naloxone 2mg/kg BW in all regions except the GN where it is diminished 60%. βC-7 causes bizarre behavior beginning 60s after infusion is started. GD-7 causes no behavioral change. These findings suggest GD-7 gains access to brain cells by diffusion through circumventricular organs while βC-7 passes the BBB by carrier facilitation.

Original languageEnglish (US)
Pages (from-to)321-323
Number of pages3
JournalPeptides
Volume24
Issue number2
DOIs
StatePublished - Feb 1 2003
Externally publishedYes

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Geniculate Bodies
Naloxone
Rats
Brain
Hippocampus
Circumventricular Organs

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Findings in normal rats following administration of gliadorphin-7 (GD-7). / Sun, Zhongjie; Cade, Robert.

In: Peptides, Vol. 24, No. 2, 01.02.2003, p. 321-323.

Research output: Contribution to journalArticle

Sun, Zhongjie ; Cade, Robert. / Findings in normal rats following administration of gliadorphin-7 (GD-7). In: Peptides. 2003 ; Vol. 24, No. 2. pp. 321-323.
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