Flow cytometric analysis of pulmonary fluids and cells for the detection of malignancies

J. E. Fuhr, A. A. Kattine, T. A. Sullivan, Henry Nelson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Cells from a pulmonary or bronchial origin were analyzed with flow cytometry to assess the sensitivity and specificity of this method in diagnosing malignancy. In all instances, cells submitted for flow cytometry analysis were excess cells from specimens submitted for routine cytology. Less than 3% of all samples were rejected for insufficient material. Over-all sensitivity from all sources was 86%, specificity 96%. Although cytology results were the standard for determining accuracy of flow cytometry, in a few patients cytology appeared normal and initial evidence for malignancy was obtained from flow cytometry. For this reason, flow cytometry may be a valuable adjunctive technology in the diagnosis of malignancy.

Original languageEnglish (US)
Pages (from-to)211-215
Number of pages5
JournalAmerican Journal of Pathology
Volume141
Issue number1
StatePublished - Jan 1 1992

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Flow Cytometry
Lung
Cell Biology
Neoplasms
Technology
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Flow cytometric analysis of pulmonary fluids and cells for the detection of malignancies. / Fuhr, J. E.; Kattine, A. A.; Sullivan, T. A.; Nelson, Henry.

In: American Journal of Pathology, Vol. 141, No. 1, 01.01.1992, p. 211-215.

Research output: Contribution to journalArticle

Fuhr, J. E. ; Kattine, A. A. ; Sullivan, T. A. ; Nelson, Henry. / Flow cytometric analysis of pulmonary fluids and cells for the detection of malignancies. In: American Journal of Pathology. 1992 ; Vol. 141, No. 1. pp. 211-215.
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