Flow velocity waveforms of the umbilical and cerebral arteries before and after intravascular transfusion

Giancarlo Mari, Kenneth J. Moise, Russell L. Deter, Robert J. Carpenter

Research output: Contribution to journalArticle

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Abstract

Thirteen intravascular transfusions were performed in 13 human fetuses who were anemic because of severe red-cell alloimmunization. To investigate the status of the umbilical and cerebral circulations by pulsed Doppler ultrasound, we studied the fetal middle cerebral artery (N = 13), internal carotid artery (N = 11), anterior cerebral artery (N = 11), and umbilical artery (N = 13) before, within the first 2 hours after, and the day after intravascular transfusion. The gestational age at the time of transfusion was 21–31 weeks (mean ± SD 25 ± 3.1). The fetal hematocrits before transfusion ranged from 12–32% (23.4 ± 6.1), whereas the hematocrit after transfusion was between 25–42% (35 ± 5). The net blood volume transfused (volume infused - volume removed) ranged between 7.5–31.0 mL (16.0 ± 7.4). The hematocrit of the transfused blood varied between 68–81% (74 ± 4). Repeated-measures analysis of variance indicated significant differences in the pulsatility index values of the four vessels studied. The same analysis indicated significant differences in the pulsatility index values at the three time points. Multiple comparison tests showed that the pulsatility index was reduced significantly immediately after transfusion for each vessel studied, but returned to pretransfusion levels by the next day. These data suggest a change in vascular impedance soon after transfusion as a consequence of direct intravascular transfusion.

Original languageEnglish (US)
Pages (from-to)584-589
Number of pages6
JournalObstetrics and Gynecology
Volume75
Issue number4
StatePublished - 1990
Externally publishedYes

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Umbilical Arteries
Cerebral Arteries
Hematocrit
Cerebrovascular Circulation
Anterior Cerebral Artery
Umbilicus
Doppler Ultrasonography
Middle Cerebral Artery
Internal Carotid Artery
Blood Volume
Electric Impedance
Gestational Age
Blood Vessels
Analysis of Variance
Fetus

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Flow velocity waveforms of the umbilical and cerebral arteries before and after intravascular transfusion. / Mari, Giancarlo; Moise, Kenneth J.; Deter, Russell L.; Carpenter, Robert J.

In: Obstetrics and Gynecology, Vol. 75, No. 4, 1990, p. 584-589.

Research output: Contribution to journalArticle

Mari, Giancarlo ; Moise, Kenneth J. ; Deter, Russell L. ; Carpenter, Robert J. / Flow velocity waveforms of the umbilical and cerebral arteries before and after intravascular transfusion. In: Obstetrics and Gynecology. 1990 ; Vol. 75, No. 4. pp. 584-589.
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