Fluoride dentifrice containing xylitol

In vitro root caries formation

Franklin Garcia-Godoy, K. A O Lisa Marie, Catherine M. Flaitz, John Hicks

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: To evaluate the effects of experimental xylitol dentifrices with and without fluoride on in vitro root caries formation. Methods: Root surfaces from caries-free human permanent teeth (n=10) underwent debridement and a fluoride-free prophylaxis. The tooth roots were sectioned into quarters, and acid-resistant varnish was placed with two sound root surface windows exposed on each tooth quarter. Each quarter from a single tooth was assigned to a treatment group: (1) No treatment control; (2) Aquafresh Advanced (0.15% F = 1,150 ppm F); (3) Experimental xylitol dentifrice without fluoride (0.45% xylitol); and (4) Diamynt fluoride dentifrice with xylitol (0.83% sodium monofluorophosphate = 1,100 ppm F and 0.20% xylitol). Tooth root quarters were treated with fresh dentifrice twice daily (3 minutes) followed by fresh synthetic saliva rinsing oyer a 7-day period. Controls were exposed twice daily to fresh synthetic saliva rinsing daily over a 7-day period. In vitro root caries were created using an acidified gel (pH 4.25, 21 days). Longitudinal sections (three sections/tooth quarter, 60/group) were evaluated for mean lesion depths (water inhibition, polarized light, ANOVA, DMR). Results: Mean lesion depths were 359 ± 37 //m for the control Group; 280 ± 28 μm for Aquafresh Advanced; 342 ± 41 μm for the experimental xylitol dentifrice without fluoride; and 261 ± 34 μm for Diamynt. Aquafresh Advanced and Diamynt had mean lesion depths significantly less than those for the no treatment control and the experimental xylitol without fluoride dentifrice (P< 0.05). There were minimal non-significant differences in mean lesion depths between Aquafresh Advanced and Diamynt (P> 0.05). (Am J Dent 2013;26:56-60).

Original languageEnglish (US)
Pages (from-to)56-60
Number of pages5
JournalAmerican Journal of Dentistry
Volume26
Issue number1
StatePublished - Feb 2013

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Root Caries
Dentifrices
Xylitol
Fluorides
Tooth
Tooth Root
fluorophosphate
Saliva
Paint
Debridement
In Vitro Techniques
Analysis of Variance
Gels
Light
Control Groups
Acids
Water

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

Garcia-Godoy, F., Lisa Marie, K. A. O., Flaitz, C. M., & Hicks, J. (2013). Fluoride dentifrice containing xylitol: In vitro root caries formation. American Journal of Dentistry, 26(1), 56-60.

Fluoride dentifrice containing xylitol : In vitro root caries formation. / Garcia-Godoy, Franklin; Lisa Marie, K. A O; Flaitz, Catherine M.; Hicks, John.

In: American Journal of Dentistry, Vol. 26, No. 1, 02.2013, p. 56-60.

Research output: Contribution to journalArticle

Garcia-Godoy, F, Lisa Marie, KAO, Flaitz, CM & Hicks, J 2013, 'Fluoride dentifrice containing xylitol: In vitro root caries formation', American Journal of Dentistry, vol. 26, no. 1, pp. 56-60.
Garcia-Godoy, Franklin ; Lisa Marie, K. A O ; Flaitz, Catherine M. ; Hicks, John. / Fluoride dentifrice containing xylitol : In vitro root caries formation. In: American Journal of Dentistry. 2013 ; Vol. 26, No. 1. pp. 56-60.
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abstract = "Purpose: To evaluate the effects of experimental xylitol dentifrices with and without fluoride on in vitro root caries formation. Methods: Root surfaces from caries-free human permanent teeth (n=10) underwent debridement and a fluoride-free prophylaxis. The tooth roots were sectioned into quarters, and acid-resistant varnish was placed with two sound root surface windows exposed on each tooth quarter. Each quarter from a single tooth was assigned to a treatment group: (1) No treatment control; (2) Aquafresh Advanced (0.15{\%} F = 1,150 ppm F); (3) Experimental xylitol dentifrice without fluoride (0.45{\%} xylitol); and (4) Diamynt fluoride dentifrice with xylitol (0.83{\%} sodium monofluorophosphate = 1,100 ppm F and 0.20{\%} xylitol). Tooth root quarters were treated with fresh dentifrice twice daily (3 minutes) followed by fresh synthetic saliva rinsing oyer a 7-day period. Controls were exposed twice daily to fresh synthetic saliva rinsing daily over a 7-day period. In vitro root caries were created using an acidified gel (pH 4.25, 21 days). Longitudinal sections (three sections/tooth quarter, 60/group) were evaluated for mean lesion depths (water inhibition, polarized light, ANOVA, DMR). Results: Mean lesion depths were 359 ± 37 //m for the control Group; 280 ± 28 μm for Aquafresh Advanced; 342 ± 41 μm for the experimental xylitol dentifrice without fluoride; and 261 ± 34 μm for Diamynt. Aquafresh Advanced and Diamynt had mean lesion depths significantly less than those for the no treatment control and the experimental xylitol without fluoride dentifrice (P< 0.05). There were minimal non-significant differences in mean lesion depths between Aquafresh Advanced and Diamynt (P> 0.05). (Am J Dent 2013;26:56-60).",
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