Follicular lymphomas with plasmacytic differentiation include two subtypes

Joel Gradowski, Elaine S. Jaffe, Roger A. Warnke, Stefania Pittaluga, Urvashi Surti, Leena A. Gole, Steven H. Swerdlow

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Abstract

Follicular lymphomas with plasmacytic differentiation were described more than two decades ago. However, the possibility that some of these reported cases are marginal zone lymphomas or composite lymphomas must be considered. In addition, it is also uncertain whether follicular lymphomas with plasmacytic differentiation have any unique cytogenetic or other features. Therefore, fluorescence immunophenotypic and interphase cytogenetic analysis of 14 well-characterized follicular lymphomas with plasmacytic differentiation was performed using a CD138 antibody to identify the plasma cells and with BCL2, BCL6, IGH@ and MALT1 break-apart probes and a chromosome 12 centromeric probe. CD10 was expressed in 12/14 cases, BCL6 in 12/12 cases and BCL2 in 12/14 cases. At least one cytogenetic abnormality was identified in 12/14 cases. The same abnormality was present in both the plasmacytic (CD138) and non-plasmacytic (CD138) component in all 10 evaluable cases. BCL2 rearrangements were present in seven cases (5 IGH@ rearranged, 1 IGH@-not rearranged, 1 IGH@-not evaluable), BCL6 rearrangement in two (1 also with BCL2/IGH@ rearrangement), 12 in 1, MALT1 without 18 in 1, IGH@ rearrangement without other abnormalities in 1 and IGH@ rearranged or partially deleted in 1 case. No cases showed BCL6 (3q27) or a MALT1 rearrangement. All six cases with an isolated BCL2 rearrangement had predominantly interfollicular plasmacytic cells whereas, 6/7 cases without the translocation had concentrations of intrafollicular or perifollicular plasmacytic cells (P0.005), as did the case with BCL2 and BCL6 translocations. These results support the existence of bona fide follicular lymphomas with plasmacytic differentiation and support the clonal relationship of the neoplastic lymphoid and plasma cells in at least most of these cases. The differential distribution of the plasma cells, specifically in relation to the presence or absence of an isolated BCL2 rearrangement suggests that the latter cases may be distinctive, sharing some features with marginal zone lymphomas.

Original languageEnglish (US)
Pages (from-to)71-79
Number of pages9
JournalModern Pathology
Volume23
Issue number1
DOIs
StatePublished - Jan 1 2010

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Follicular Lymphoma
Plasma Cells
Composite Lymphoma
Lymphoma
Chromosomes, Human, Pair 12
Cytogenetic Analysis
Interphase
Cytogenetics
Chromosome Aberrations
Fluorescence
Lymphocytes
Antibodies

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Gradowski, J., Jaffe, E. S., Warnke, R. A., Pittaluga, S., Surti, U., Gole, L. A., & Swerdlow, S. H. (2010). Follicular lymphomas with plasmacytic differentiation include two subtypes. Modern Pathology, 23(1), 71-79. https://doi.org/10.1038/modpathol.2009.146

Follicular lymphomas with plasmacytic differentiation include two subtypes. / Gradowski, Joel; Jaffe, Elaine S.; Warnke, Roger A.; Pittaluga, Stefania; Surti, Urvashi; Gole, Leena A.; Swerdlow, Steven H.

In: Modern Pathology, Vol. 23, No. 1, 01.01.2010, p. 71-79.

Research output: Contribution to journalArticle

Gradowski, J, Jaffe, ES, Warnke, RA, Pittaluga, S, Surti, U, Gole, LA & Swerdlow, SH 2010, 'Follicular lymphomas with plasmacytic differentiation include two subtypes', Modern Pathology, vol. 23, no. 1, pp. 71-79. https://doi.org/10.1038/modpathol.2009.146
Gradowski, Joel ; Jaffe, Elaine S. ; Warnke, Roger A. ; Pittaluga, Stefania ; Surti, Urvashi ; Gole, Leena A. ; Swerdlow, Steven H. / Follicular lymphomas with plasmacytic differentiation include two subtypes. In: Modern Pathology. 2010 ; Vol. 23, No. 1. pp. 71-79.
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