Frequencies of apolipoprotein E polymorphism in a healthy Kurdish population from Kermanshah, Iran

Asad Vaisi-Raygani, Hadi Kharrazi, Zohreh Rahimi, Tayebeh Pourmotabbed

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The molecular polymorphism displayed by apolipoprotein E (APOE) has been listed as a risk factor for susceptibility to various disorders, such as those associated with lipid metabolism, arteriosclerosis, coronary artery disease (CAD), and Alzheimer disease. To evaluate the role of APOE genotypes as risk factors for Alzheimer disease, CAD, and atherosclerosis in the Kurdish population of Kermanshah, Iran, we studied the frequencies of APOE alleles *2, *3, and *4 and genotypes in 914 healthy Kurdish subjects (514 men and 400 women). The highest frequency of APOE in the Kurdish population was found for APOE*3 (87.87%). The APOE*2 and APOE*4 allele frequencies were 6.66% and 5.45%, respectively. Distribution of APOE genotypes and alleles was not significantly different between male and female subjects (p > 0.05). Interestingly, the order of the frequency of APOE alleles (*3 → *2 → *4) in the Kurdish population was quite different from that reported for most populations in the world (*3 → *4 → *2). The findings of the present study can be used to identify individuals with high risk of CAD and atherosclerosis and suggest a preventive measure to reduce their susceptibility.

Original languageEnglish (US)
Pages (from-to)579-587
Number of pages9
JournalHuman Biology
Volume79
Issue number5
DOIs
StatePublished - Jan 1 2007

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apolipoprotein E
Apolipoproteins E
Iran
Coronary Artery Disease
polymorphism
genetic polymorphism
allele
Apolipoprotein E2
Apolipoprotein E3
genotype
Population
Alleles
Genotype
risk factor
Alzheimer Disease
Apolipoprotein E4
Alzheimer disease
Arteriosclerosis
atherosclerosis
alleles

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

Cite this

Frequencies of apolipoprotein E polymorphism in a healthy Kurdish population from Kermanshah, Iran. / Vaisi-Raygani, Asad; Kharrazi, Hadi; Rahimi, Zohreh; Pourmotabbed, Tayebeh.

In: Human Biology, Vol. 79, No. 5, 01.01.2007, p. 579-587.

Research output: Contribution to journalArticle

Vaisi-Raygani, Asad ; Kharrazi, Hadi ; Rahimi, Zohreh ; Pourmotabbed, Tayebeh. / Frequencies of apolipoprotein E polymorphism in a healthy Kurdish population from Kermanshah, Iran. In: Human Biology. 2007 ; Vol. 79, No. 5. pp. 579-587.
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