Frequency of nonresponse antiplatelet activity of Clopidogrel during pretreatment for cardiac catheterization

Joseph E. Mobley, Stuart Bresee, Dale Wortham, Robert Craft, Carolyn C. Snider, Roger C. Carroll

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

Platelet function was evaluated before and after clopidogrel therapy in 50 cardiology candidates scheduled for intervention; results were averaged from optical platelet aggregation with 2 significantly correlated point-of-care instruments, Thrombelastograph and Ichor PlateletWorks. Although this was a limited study with few complications, the failure of clopidogrel therapy (30% nonresponders with <10% average platelet inhibition) was not correlated with clinical pretreatment variables, including atorvastatin therapy, postintervention bleeding complications, or major adverse coronxary events.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalAmerican Journal of Cardiology
Volume93
Issue number4
DOIs
StatePublished - Feb 15 2004

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clopidogrel
Cardiac Catheterization
Blood Platelets
Point-of-Care Systems
Cardiology
Platelet Aggregation
Therapeutics
Hemorrhage

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Frequency of nonresponse antiplatelet activity of Clopidogrel during pretreatment for cardiac catheterization. / Mobley, Joseph E.; Bresee, Stuart; Wortham, Dale; Craft, Robert; Snider, Carolyn C.; Carroll, Roger C.

In: American Journal of Cardiology, Vol. 93, No. 4, 15.02.2004, p. 456-458.

Research output: Contribution to journalArticle

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