Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers

Paul Terry, J. Lagergren, H. Hansen, A. Wolk, O. Nyrén

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The incidence of adenocarcinoma of the oesophagus has increased rapidly in recent decades. In order to appreciate the potential for prevention by means of dietary modification, we estimated the aetiological fractions and the increments in absolute risk attributable to low intake of fruit and vegetables for adenocarcinoma and squamous cell carcinoma of the oesophagus and for adenocarcinoma of the gastroesophageal junction. We conducted a nationwide population-based case-control study in Sweden, with participation of 608 cases and 815 controls. We used unconditional logistic regression to estimate relative risks, from which we calculated aetiological fractions. Individuals in the highest exposure quartile (median 4.8 servings/day) versus the lowest (median 1.5 servings/day) showed approximately 50% lower risk of oesophageal adenocarcinoma and 40% lower risk of oesophageal squamous cell carcinoma, but no risk reduction for gastric cardia adenocarcinoma. Approximately 20% of oesophageal adenocarcinoma, and likewise squamous cell carcinoma, in Sweden was attributed to consuming less than three servings of fruit and vegetables per day. A very large number of individuals (over 25 000) would need to increase their fruit and vegetable consumption moderately in order to prevent one oesophageal cancer per year. Moderate relative risk reductions translate into weak absolute risk reductions for oesophageal cancers in Sweden.

Original languageEnglish (US)
Pages (from-to)365-369
Number of pages5
JournalEuropean Journal of Cancer Prevention
Volume10
Issue number4
DOIs
StatePublished - Aug 21 2001

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Cardia
Esophageal Neoplasms
Vegetables
Fruit
Adenocarcinoma
Sweden
Risk Reduction Behavior
Squamous Cell Carcinoma
Diet Therapy
Numbers Needed To Treat
Esophagogastric Junction
Case-Control Studies
Stomach
Logistic Models
Incidence
Population

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology
  • Public Health, Environmental and Occupational Health
  • Cancer Research

Cite this

Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. / Terry, Paul; Lagergren, J.; Hansen, H.; Wolk, A.; Nyrén, O.

In: European Journal of Cancer Prevention, Vol. 10, No. 4, 21.08.2001, p. 365-369.

Research output: Contribution to journalArticle

Terry, Paul ; Lagergren, J. ; Hansen, H. ; Wolk, A. ; Nyrén, O. / Fruit and vegetable consumption in the prevention of oesophageal and cardia cancers. In: European Journal of Cancer Prevention. 2001 ; Vol. 10, No. 4. pp. 365-369.
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