Fruit, vegetables, dietary fiber, and risk of colorectal cancer

Paul Terry, Edward Giovannucci, Karin B. Michels, Leif Bergkvist, Holger Hansen, Lars Holmberg, Alicja Wolk

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

Background: Several recent large prospective cohort studies have failed to demonstrate the presumed protective effect of fruit, vegetable, and dietary fiber consumption on colorectal cancer risk. To further explore this issue, we have examined these associations in a population that consumes relatively low amounts of fruit and vegetables and high amounts of cereals. Methods: We examined data obtained from a food-frequency questionnaire used in a population-based prospective mammography screening study of women in central Sweden. Women with colorectal cancer diagnosed through December 31, 1998, were identified by linkage to regional cancer registries. Cox proportional hazards models were used to estimate relative risks. All statistical tests were two-sided. Results: During an average 9.6 years of follow-up of 61463 women, we observed 460 incident cases of colorectal cancer (291 colon cancers, 159 rectal cancers, and 10 cancers at both sites). In the entire study population, total fruit and vegetable consumption was inversely associated with colorectal cancer risk. Subanalyses showed that this association was due largely to fruit consumption. The association was stronger, however, and the dose-response effect was more evident among individuals who consumed the lowest amounts of fruit and vegetables. Individuals who consumed less than 1.5 servings of fruit and vegetables per day had a relative risk for developing colorectal cancer of 1.65 (95% confidence interval = 1.23 to 2.20; Ptrend = .001) compared with individuals who consumed more than 2.5 servings. We observed no association between colorectal cancer risk and the consumption of cereal fiber, even at amounts substantially greater than previously examined, or of non-cereal fiber. Conclusions: Individuals who consume very low amounts of fruit and vegetables have the greatest risk of colorectal cancer. Relatively high consumption of cereal fiber does not appear to lower the risk of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)525-533
Number of pages9
JournalJournal of the National Cancer Institute
Volume93
Issue number7
DOIs
StatePublished - Apr 4 2001
Externally publishedYes

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Dietary Fiber
Vegetables
Colorectal Neoplasms
Fruit
Colonic Neoplasms
Population
Mammography
Rectal Neoplasms
Proportional Hazards Models
Sweden
Registries
Neoplasms
Cohort Studies
Prospective Studies
Confidence Intervals
Food

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Terry, P., Giovannucci, E., Michels, K. B., Bergkvist, L., Hansen, H., Holmberg, L., & Wolk, A. (2001). Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute, 93(7), 525-533. https://doi.org/10.1093/jnci/93.7.525

Fruit, vegetables, dietary fiber, and risk of colorectal cancer. / Terry, Paul; Giovannucci, Edward; Michels, Karin B.; Bergkvist, Leif; Hansen, Holger; Holmberg, Lars; Wolk, Alicja.

In: Journal of the National Cancer Institute, Vol. 93, No. 7, 04.04.2001, p. 525-533.

Research output: Contribution to journalArticle

Terry, P, Giovannucci, E, Michels, KB, Bergkvist, L, Hansen, H, Holmberg, L & Wolk, A 2001, 'Fruit, vegetables, dietary fiber, and risk of colorectal cancer', Journal of the National Cancer Institute, vol. 93, no. 7, pp. 525-533. https://doi.org/10.1093/jnci/93.7.525
Terry P, Giovannucci E, Michels KB, Bergkvist L, Hansen H, Holmberg L et al. Fruit, vegetables, dietary fiber, and risk of colorectal cancer. Journal of the National Cancer Institute. 2001 Apr 4;93(7):525-533. https://doi.org/10.1093/jnci/93.7.525
Terry, Paul ; Giovannucci, Edward ; Michels, Karin B. ; Bergkvist, Leif ; Hansen, Holger ; Holmberg, Lars ; Wolk, Alicja. / Fruit, vegetables, dietary fiber, and risk of colorectal cancer. In: Journal of the National Cancer Institute. 2001 ; Vol. 93, No. 7. pp. 525-533.
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