Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy

Rajeshkumar Bhalodolia, Cherise Cortese, Michael Graham, Paul Hauptman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We present a case of a heart transplant recipient who had new-onset heart failure, repeatedly unremarkable endomyocardial biopsies, a negative evaluation for humoral rejection, and subsequently autopsy findings of severe sub-epicardial myocyte necrosis with classic cellular rejection. The sub-endocardial layer was free from rejection. The implications for clinical management, in the context of a diagnosis of "biopsy-negative rejection with hemodynamic compromise," include the need to consider intensification of immunosuppression with regimens similar to those used for biopsy-proven rejection.

Original languageEnglish (US)
Pages (from-to)989-992
Number of pages4
JournalJournal of Heart and Lung Transplantation
Volume25
Issue number8
DOIs
StatePublished - Aug 1 2006
Externally publishedYes

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Biopsy
Immunosuppression
Muscle Cells
Autopsy
Necrosis
Heart Failure
Hemodynamics
Transplant Recipients

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine
  • Transplantation

Cite this

Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy. / Bhalodolia, Rajeshkumar; Cortese, Cherise; Graham, Michael; Hauptman, Paul.

In: Journal of Heart and Lung Transplantation, Vol. 25, No. 8, 01.08.2006, p. 989-992.

Research output: Contribution to journalArticle

Bhalodolia, Rajeshkumar ; Cortese, Cherise ; Graham, Michael ; Hauptman, Paul. / Fulminant Acute Cellular Rejection With Negative Findings on Endomyocardial Biopsy. In: Journal of Heart and Lung Transplantation. 2006 ; Vol. 25, No. 8. pp. 989-992.
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