Functional connectivity in tuberous sclerosis complex with autistic spectrum disorder preliminary findings

Roozbeh Rezaie, George Zouridakis, Asim Choudhri, James Wheless, Eszter Völgyi, Katherine Van Poppel, Nancy R. Clanton, Andrew Papanicolaou

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Despite the frequent occurrence of autism spectrum disorder (ASD) in tuberous sclerosis complex (TSC), the neurophysiological factors that distinguish children with TSC from children with TSC presenting with ASD symptoms remain unspecified. Growing evidence suggests that ASD may be characterized by atypical structural and functional connectivity between specific cortical regions. In this exploratory study, we utilized magnetoencephalography to derive resting brain connectivity patterns, in an attempt to identify neurophysiological markers that may differentiate TSC children with ASD (n=2) from TSC children without ASD (n=2) and typically developing children (n=2). Connectivity pattern analysis revealed that TSC children presenting with ASD symptoms can be distinguished from TSC and typically developing children by the presence of long-range, medial, anterior-posterior connections previously observed in adolescents with ASD. While preliminary in nature, our findings support the notion that altered functional connectivity may be a constituent characteristic of ASD and may enable prediction of which TSC children are likely to develop ASD and facilitate early behavioral and medical intervention.

Original languageEnglish (US)
Pages (from-to)79-82
Number of pages4
JournalJournal of Pediatric Neurology
Volume11
Issue number2
DOIs
StatePublished - May 7 2013

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Tuberous Sclerosis
Autistic Disorder
Early Medical Intervention
Autism Spectrum Disorder
Magnetoencephalography
Brain

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Functional connectivity in tuberous sclerosis complex with autistic spectrum disorder preliminary findings. / Rezaie, Roozbeh; Zouridakis, George; Choudhri, Asim; Wheless, James; Völgyi, Eszter; Van Poppel, Katherine; Clanton, Nancy R.; Papanicolaou, Andrew.

In: Journal of Pediatric Neurology, Vol. 11, No. 2, 07.05.2013, p. 79-82.

Research output: Contribution to journalArticle

Rezaie, Roozbeh ; Zouridakis, George ; Choudhri, Asim ; Wheless, James ; Völgyi, Eszter ; Van Poppel, Katherine ; Clanton, Nancy R. ; Papanicolaou, Andrew. / Functional connectivity in tuberous sclerosis complex with autistic spectrum disorder preliminary findings. In: Journal of Pediatric Neurology. 2013 ; Vol. 11, No. 2. pp. 79-82.
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