Functional connectivity networks in the autistic and healthy brain assessed using Granger causality

Luca Pollonini, Udit Patidar, Ning Situ, Roozbeh Rezaie, Andrew Papanicolaou, George Zouridakis

Research output: Chapter in Book/Report/Conference proceedingConference contribution

41 Citations (Scopus)

Abstract

In this study, we analyze brain connectivity based on Granger causality computed from magnetoencephalographic (MEG) activity obtained at the resting state in eight autistic and eight normal subjects along with measures of network connectivity derived from graph theory in an attempt to understand how communication in a human brain network is affected by autism. A connectivity matrix was computed for each subject individually and then group templates were estimated by averaging all matrices in each group. Furthermore, we performed classification of the subjects using support vector machines and Fisher's criterion to rank the features and identify the best subset for maximum separation of the groups. Our results show that a combined model based on connectivity matrices and graph theory measures can provide 87.5% accuracy in separating the two groups. These findings suggest that analysis of functional connectivity patterns may provide a valuable method for the early detection of autism.

Original languageEnglish (US)
Title of host publication2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Pages1730-1733
Number of pages4
DOIs
StatePublished - Dec 1 2010
Event2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 - Buenos Aires, Argentina
Duration: Aug 31 2010Sep 4 2010

Publication series

Name2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10

Other

Other2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
CountryArgentina
CityBuenos Aires
Period8/31/109/4/10

Fingerprint

Autistic Disorder
Causality
Brain
Graph theory
Communication
Support vector machines
Support Vector Machine

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Health Informatics

Cite this

Pollonini, L., Patidar, U., Situ, N., Rezaie, R., Papanicolaou, A., & Zouridakis, G. (2010). Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10 (pp. 1730-1733). [5626702] (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5626702

Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. / Pollonini, Luca; Patidar, Udit; Situ, Ning; Rezaie, Roozbeh; Papanicolaou, Andrew; Zouridakis, George.

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1730-1733 5626702 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Pollonini, L, Patidar, U, Situ, N, Rezaie, R, Papanicolaou, A & Zouridakis, G 2010, Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. in 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10., 5626702, 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, pp. 1730-1733, 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10, Buenos Aires, Argentina, 8/31/10. https://doi.org/10.1109/IEMBS.2010.5626702
Pollonini L, Patidar U, Situ N, Rezaie R, Papanicolaou A, Zouridakis G. Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. In 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. p. 1730-1733. 5626702. (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10). https://doi.org/10.1109/IEMBS.2010.5626702
Pollonini, Luca ; Patidar, Udit ; Situ, Ning ; Rezaie, Roozbeh ; Papanicolaou, Andrew ; Zouridakis, George. / Functional connectivity networks in the autistic and healthy brain assessed using Granger causality. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10. 2010. pp. 1730-1733 (2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10).
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