Functional neuroimaging with MEG

Normative language profiles

Andrew Papanicolaou, P. Pazo-Alvarez, E. M. Castillo, R. L. Billingsley-Marshall, J. I. Breier, P. R. Swank, S. Buchanan, M. McManis, T. Clear, A. D. Passaro

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The reliability of language-specific brain activation profiles was assessed using Magnetoencephalography (MEG) in five experiments involving ninety-seven normal volunteers of both genders ranging in age from seven to eighty-four years. MEG data were analyzed with a fully automated method to eliminate subjective judgments in the process of deriving the activation profiles. Across all experiments, profiles were characterized by significant bilateral activity centered in the superior temporal gyrus, and in activity lateralized to the left middle temporal gyrus. These features were invariant across age, gender, variation in task characteristics, and mode of stimulus presentation. The absolute amount of activation, however, did decline with age in the auditory tasks. Moreover, contrary to the commonly held belief that left hemisphere dominance for language is greater in men than in women, our data revealed an opposite albeit a not consistently significant trend.

Original languageEnglish (US)
Pages (from-to)326-342
Number of pages17
JournalNeuroImage
Volume33
Issue number1
DOIs
StatePublished - Oct 15 2006

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Magnetoencephalography
Functional Neuroimaging
Temporal Lobe
Language
Healthy Volunteers
Brain

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Papanicolaou, A., Pazo-Alvarez, P., Castillo, E. M., Billingsley-Marshall, R. L., Breier, J. I., Swank, P. R., ... Passaro, A. D. (2006). Functional neuroimaging with MEG: Normative language profiles. NeuroImage, 33(1), 326-342. https://doi.org/10.1016/j.neuroimage.2006.06.020

Functional neuroimaging with MEG : Normative language profiles. / Papanicolaou, Andrew; Pazo-Alvarez, P.; Castillo, E. M.; Billingsley-Marshall, R. L.; Breier, J. I.; Swank, P. R.; Buchanan, S.; McManis, M.; Clear, T.; Passaro, A. D.

In: NeuroImage, Vol. 33, No. 1, 15.10.2006, p. 326-342.

Research output: Contribution to journalArticle

Papanicolaou, A, Pazo-Alvarez, P, Castillo, EM, Billingsley-Marshall, RL, Breier, JI, Swank, PR, Buchanan, S, McManis, M, Clear, T & Passaro, AD 2006, 'Functional neuroimaging with MEG: Normative language profiles', NeuroImage, vol. 33, no. 1, pp. 326-342. https://doi.org/10.1016/j.neuroimage.2006.06.020
Papanicolaou A, Pazo-Alvarez P, Castillo EM, Billingsley-Marshall RL, Breier JI, Swank PR et al. Functional neuroimaging with MEG: Normative language profiles. NeuroImage. 2006 Oct 15;33(1):326-342. https://doi.org/10.1016/j.neuroimage.2006.06.020
Papanicolaou, Andrew ; Pazo-Alvarez, P. ; Castillo, E. M. ; Billingsley-Marshall, R. L. ; Breier, J. I. ; Swank, P. R. ; Buchanan, S. ; McManis, M. ; Clear, T. ; Passaro, A. D. / Functional neuroimaging with MEG : Normative language profiles. In: NeuroImage. 2006 ; Vol. 33, No. 1. pp. 326-342.
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