Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy

Hemraj M. Yadav, Nanasaheb D. Thorat, Murali Yallapu, Syed A M Tofail, Jung Sik Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG). TiO2 nanocoral-like structures were synthesized by optimizing a solvothermal method. The developed nanocoral structures were efficiently conjugated with chemotherapeutic drugs on the surfaces of the TiO2 nanoparticles. The mPEG on the surfaces of the multifunctional nanocorals effectively conjugated the drug and improved the biocompatibility of the nanocorals. Following UV light irradiation, the TiO2 nanocorals produce free radicals (.OH and .O2 -) and are effective for drug release in cancer cells. Importantly, the amount of drug released from the multimodal TiO2 nanocorals can be regulated by UV-light irradiation time, which allows for further control of the anti-cancer effect. The multimodal TiO2 nanocorals exhibit a combination of light-activated, stimuli-triggered drug release for killing of cancer cell. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in MCF7 cells. Our results showed that nanocoral-DOX complexes exhibited a greater cytotoxicity toward MCF7 cells than free DOX. Our work demonstrates that the therapeutic efficacy of DOX-loaded TiO2 nanocorals is strongly dependent on their loading mode and the chemotherapeutic effect is improved under UV light illumination, which provides a significant breakthrough for future applications of TiO2 as a light activated drug carrier in cancer chemotherapy.

Original languageEnglish (US)
Pages (from-to)1461-1470
Number of pages10
JournalJournal of Materials Chemistry B
Volume5
Issue number7
DOIs
StatePublished - 2017

Fingerprint

Chemotherapy
Ultraviolet radiation
Cytotoxicity
Light
Drug Therapy
Ultraviolet Rays
Polyethylene glycols
Cells
Irradiation
Pharmaceutical Preparations
MCF-7 Cells
Neoplasms
Free radicals
Biocompatibility
Titanium dioxide
Lighting
Drug Carriers
Nanoparticles
Free Radicals
Drug Liberation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Medicine(all)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy. / Yadav, Hemraj M.; Thorat, Nanasaheb D.; Yallapu, Murali; Tofail, Syed A M; Kim, Jung Sik.

In: Journal of Materials Chemistry B, Vol. 5, No. 7, 2017, p. 1461-1470.

Research output: Contribution to journalArticle

Yadav, Hemraj M. ; Thorat, Nanasaheb D. ; Yallapu, Murali ; Tofail, Syed A M ; Kim, Jung Sik. / Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy. In: Journal of Materials Chemistry B. 2017 ; Vol. 5, No. 7. pp. 1461-1470.
@article{30e168a357ae44fe868641a19fdc86b3,
title = "Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy",
abstract = "To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG). TiO2 nanocoral-like structures were synthesized by optimizing a solvothermal method. The developed nanocoral structures were efficiently conjugated with chemotherapeutic drugs on the surfaces of the TiO2 nanoparticles. The mPEG on the surfaces of the multifunctional nanocorals effectively conjugated the drug and improved the biocompatibility of the nanocorals. Following UV light irradiation, the TiO2 nanocorals produce free radicals (.OH and .O2 -) and are effective for drug release in cancer cells. Importantly, the amount of drug released from the multimodal TiO2 nanocorals can be regulated by UV-light irradiation time, which allows for further control of the anti-cancer effect. The multimodal TiO2 nanocorals exhibit a combination of light-activated, stimuli-triggered drug release for killing of cancer cell. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in MCF7 cells. Our results showed that nanocoral-DOX complexes exhibited a greater cytotoxicity toward MCF7 cells than free DOX. Our work demonstrates that the therapeutic efficacy of DOX-loaded TiO2 nanocorals is strongly dependent on their loading mode and the chemotherapeutic effect is improved under UV light illumination, which provides a significant breakthrough for future applications of TiO2 as a light activated drug carrier in cancer chemotherapy.",
author = "Yadav, {Hemraj M.} and Thorat, {Nanasaheb D.} and Murali Yallapu and Tofail, {Syed A M} and Kim, {Jung Sik}",
year = "2017",
doi = "10.1039/c6tb02324j",
language = "English (US)",
volume = "5",
pages = "1461--1470",
journal = "Journal of Materials Chemistry B",
issn = "2050-7518",
publisher = "Royal Society of Chemistry",
number = "7",

}

TY - JOUR

T1 - Functional TiO2 nanocoral architecture for light-activated cancer chemotherapy

AU - Yadav, Hemraj M.

AU - Thorat, Nanasaheb D.

AU - Yallapu, Murali

AU - Tofail, Syed A M

AU - Kim, Jung Sik

PY - 2017

Y1 - 2017

N2 - To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG). TiO2 nanocoral-like structures were synthesized by optimizing a solvothermal method. The developed nanocoral structures were efficiently conjugated with chemotherapeutic drugs on the surfaces of the TiO2 nanoparticles. The mPEG on the surfaces of the multifunctional nanocorals effectively conjugated the drug and improved the biocompatibility of the nanocorals. Following UV light irradiation, the TiO2 nanocorals produce free radicals (.OH and .O2 -) and are effective for drug release in cancer cells. Importantly, the amount of drug released from the multimodal TiO2 nanocorals can be regulated by UV-light irradiation time, which allows for further control of the anti-cancer effect. The multimodal TiO2 nanocorals exhibit a combination of light-activated, stimuli-triggered drug release for killing of cancer cell. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in MCF7 cells. Our results showed that nanocoral-DOX complexes exhibited a greater cytotoxicity toward MCF7 cells than free DOX. Our work demonstrates that the therapeutic efficacy of DOX-loaded TiO2 nanocorals is strongly dependent on their loading mode and the chemotherapeutic effect is improved under UV light illumination, which provides a significant breakthrough for future applications of TiO2 as a light activated drug carrier in cancer chemotherapy.

AB - To achieve light-triggered drug release in cancer chemotherapy, we developed multimodal titanium dioxide (TiO2) nanocorals modified with methoxy polyethylene glycol (mPEG). TiO2 nanocoral-like structures were synthesized by optimizing a solvothermal method. The developed nanocoral structures were efficiently conjugated with chemotherapeutic drugs on the surfaces of the TiO2 nanoparticles. The mPEG on the surfaces of the multifunctional nanocorals effectively conjugated the drug and improved the biocompatibility of the nanocorals. Following UV light irradiation, the TiO2 nanocorals produce free radicals (.OH and .O2 -) and are effective for drug release in cancer cells. Importantly, the amount of drug released from the multimodal TiO2 nanocorals can be regulated by UV-light irradiation time, which allows for further control of the anti-cancer effect. The multimodal TiO2 nanocorals exhibit a combination of light-activated, stimuli-triggered drug release for killing of cancer cell. The cytotoxicity, cellular uptake, and intracellular location of the formulations were evaluated in MCF7 cells. Our results showed that nanocoral-DOX complexes exhibited a greater cytotoxicity toward MCF7 cells than free DOX. Our work demonstrates that the therapeutic efficacy of DOX-loaded TiO2 nanocorals is strongly dependent on their loading mode and the chemotherapeutic effect is improved under UV light illumination, which provides a significant breakthrough for future applications of TiO2 as a light activated drug carrier in cancer chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=85013070378&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85013070378&partnerID=8YFLogxK

U2 - 10.1039/c6tb02324j

DO - 10.1039/c6tb02324j

M3 - Article

VL - 5

SP - 1461

EP - 1470

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-7518

IS - 7

ER -