Further Characterization of LSXSS Recombinant Inbred Strains of Mice

Activating and Hypothermic Effects of Ethanol

V. Gene Erwin, Byron Jones, Richard Radcliffe

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Lines of mice selected for differential initial sensitivity to the anesthetic effects of ethanol also differ in their locomotor responses to lower doses of ethanol. Sixteen recombinant inbred strains of mice derived from long‐sleep (LS) and short‐sleep (SS) selected lines as well as inbred LS and SS mice were used in a genetic correlational study to investigate possible associations between high‐dose and low‐dose indices of initial sensitivity to ethanol. Measurements of high‐dose (4.1 g/kg) effects of ethanol were hypothermia, sleep time, and blood ethanol content at regaining of righting response, and the index of low‐dose (1.875 g/kg) sensitivity was distance traveled during a 5‐min period immediately following intraperitoneal injection with ethanol. The results indicated wide genetic variation in hypothermia and ethanol‐induced locomotor activation in a manner consistent with polygenic influence. Furthermore, correlations between low‐dose locomotor activity and hypnotic dose effects tended to be low and nonsignificant, indicating independence of inherited mechanisms underlying high‐ and low‐dose ethanol sensitivity.

Original languageEnglish (US)
Pages (from-to)200-204
Number of pages5
JournalAlcoholism: Clinical and Experimental Research
Volume14
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

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Inbred Strains Mice
Ethanol
Hypothermia
Righting Reflex
Locomotion
Intraperitoneal Injections
Hypnotics and Sedatives
Anesthetics
Sleep
Blood
Chemical activation

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Further Characterization of LSXSS Recombinant Inbred Strains of Mice : Activating and Hypothermic Effects of Ethanol. / Erwin, V. Gene; Jones, Byron; Radcliffe, Richard.

In: Alcoholism: Clinical and Experimental Research, Vol. 14, No. 2, 1990, p. 200-204.

Research output: Contribution to journalArticle

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