Future nanomedicine for the diagnosis and treatment of osteoarthritis

Lauren R. Eichaker, Hongsik Cho, Craig L. Duvall, Thomas A. Werfel, Karen Hasty

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Current treatments for osteoarthritis (OA) are largely palliative until the joints become totally dysfunctional and prosthetic replacement becomes necessary. Effective methods are needed for diagnosing OA and monitoring its progression during its early stages, when the effects of therapeutic drugs or biological agents are most likely to be effective. Theranostic nanosomes and nanoparticles have the potential to noninvasively detect, track and treat the early stages of OA. As articular cartilage does not regenerate once it is degraded, cell-based treatments aided by superparamagnetic iron oxide nanoparticle tracking are attractive future treatment modalities for the later stages of OA progression, when significant cartilage replacement is needed. This article will describe the current and future translational approaches for the detection and noninvasive treatment of degenerative OA.

Original languageEnglish (US)
Pages (from-to)2203-2215
Number of pages13
JournalNanomedicine
Volume9
Issue number14
DOIs
StatePublished - Oct 1 2014

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Nanomedicine
Medical nanotechnology
Cartilage
Osteoarthritis
replacement
Nanoparticles
Biological Factors
Prosthetics
Iron oxides
iron oxide
drug
monitoring
Monitoring
Therapeutics
Pharmaceutical Preparations
Articular Cartilage
Therapeutic Uses
Joints
nanoparticle
ferric oxide

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Bioengineering
  • Biomedical Engineering
  • Development
  • Materials Science(all)

Cite this

Future nanomedicine for the diagnosis and treatment of osteoarthritis. / Eichaker, Lauren R.; Cho, Hongsik; Duvall, Craig L.; Werfel, Thomas A.; Hasty, Karen.

In: Nanomedicine, Vol. 9, No. 14, 01.10.2014, p. 2203-2215.

Research output: Contribution to journalReview article

Eichaker, Lauren R. ; Cho, Hongsik ; Duvall, Craig L. ; Werfel, Thomas A. ; Hasty, Karen. / Future nanomedicine for the diagnosis and treatment of osteoarthritis. In: Nanomedicine. 2014 ; Vol. 9, No. 14. pp. 2203-2215.
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