Gadolinium-labeled liposomes containing amphiphilic Gd-DTPA derivatives of varying chain length: Targeted MRI contrast enhancement agents for the liver

George Kabalka, M. A. Davis, E. Holmberg, K. Maruyama, L. Huang

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Paramagnetic liposomal contrast agents were synthesized and utilized for selective augmentation of T 1 MR imaging of the livers of normal Balb c mice. Amphiphilic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that they become an integral part of its surface. The amphiphilic complexing agents consisted of DTPA reagents in which a pair of alkyl chains of varying lengths are attached via amide linkages. The in vivo lifetimes of the amphiphilic agents were found to be dependent on the chain length of the alkyl groups.

Original languageEnglish (US)
Pages (from-to)373-377
Number of pages5
JournalMagnetic Resonance Imaging
Volume9
Issue number3
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Fingerprint

Gadolinium DTPA
Liposomes
Gadolinium
Chain length
Surface-Active Agents
Liver
Magnetic resonance imaging
Contrast Media
Derivatives
Unilamellar Liposomes
Pentetic Acid
Amides
Phospholipids
Imaging techniques

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Gadolinium-labeled liposomes containing amphiphilic Gd-DTPA derivatives of varying chain length : Targeted MRI contrast enhancement agents for the liver. / Kabalka, George; Davis, M. A.; Holmberg, E.; Maruyama, K.; Huang, L.

In: Magnetic Resonance Imaging, Vol. 9, No. 3, 01.01.1991, p. 373-377.

Research output: Contribution to journalArticle

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