Gadolinium-labeled liposomes

Targeted MR contrast agents for the liver and spleen

George Kabalka, E. Buonocore, Karl Hubner, T. Moss, N. Norley, L. Huang

Research output: Contribution to journalArticle

136 Citations (Scopus)

Abstract

A contrast agent for use in magnetic resonance (MR) imaging of the liver and spleen has been designed in which gadolinium-DTPA is chemically incorporated into lamellar phase of liposome particles. This agent has excellent in vivo stability and is taken up by liver and spleen of normal mice after intravenous administration. The T1 increased by 110% in liver and 66% in spleen at 4°C. At 37°, the relaxation rate in the liver increased by 180%. This method is an attractive concept for the development of various organ-specific liposomal contrast agents that may be used for either MR imaging or nuclear medicine.

Original languageEnglish (US)
Pages (from-to)255-258
Number of pages4
JournalRadiology
Volume163
Issue number1
DOIs
StatePublished - Jan 1 1987

Fingerprint

Gadolinium
Liposomes
Contrast Media
Magnetic Resonance Spectroscopy
Spleen
Liver
Magnetic Resonance Imaging
Gadolinium DTPA
Nuclear Medicine
Intravenous Administration

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Gadolinium-labeled liposomes : Targeted MR contrast agents for the liver and spleen. / Kabalka, George; Buonocore, E.; Hubner, Karl; Moss, T.; Norley, N.; Huang, L.

In: Radiology, Vol. 163, No. 1, 01.01.1987, p. 255-258.

Research output: Contribution to journalArticle

Kabalka, George ; Buonocore, E. ; Hubner, Karl ; Moss, T. ; Norley, N. ; Huang, L. / Gadolinium-labeled liposomes : Targeted MR contrast agents for the liver and spleen. In: Radiology. 1987 ; Vol. 163, No. 1. pp. 255-258.
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