Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents: Targeted MRI contrast agents for the liver

George Kabalka, E. Buonocore, Karl Hubner, M. Davis, L. Huang

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

Unique paramagnetic liposomal contrast agents were synthesized and utilized for se lective augmentation of TI MR imaging of the livers of normal Balb/c mice. Amphipathic gadolinium complexes, which mimic phospholipids, were incorporated into the lamella of small unilamellar liposomes (SUV) such that they became an integral part of its surface. T 1 signal enhancement of normal liver approached 150% after iv administra‐ tion of the paramagnetic liposomes, determined by experiments performed on a 1.9‐T, experimental whole‐body MRI unit. Tracer studies utilizing gadolinium‐ 153‐tagged SUV revealed that the agents exhibited excellent in vivo stability, compared to liposomal preparations in which paramagnetic agents are simply entrapped in the aqueous core of the liposome vesicle. © 1988 Academic Press, Inc.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalMagnetic Resonance in Medicine
Volume8
Issue number1
DOIs
StatePublished - Jan 1 1988

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Gadolinium
Liposomes
Contrast Media
Unilamellar Liposomes
Liver
Phospholipids

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Gadolinium‐labeled liposomes containing paramagnetic amphipathic agents : Targeted MRI contrast agents for the liver. / Kabalka, George; Buonocore, E.; Hubner, Karl; Davis, M.; Huang, L.

In: Magnetic Resonance in Medicine, Vol. 8, No. 1, 01.01.1988, p. 89-95.

Research output: Contribution to journalArticle

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