Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task

Michael Mcdonald, Jacqueline N. Crawley

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Galanin is a 29-amino acid neuropeptide that coexists with acetylcholine in the medial septum/diagonal band in the rat and impairs choice accuracy on an operant delayed-nonmatching-to-position (DNMTP) working-memory task. M40, a peptidergic galanin antagonist, has previously been shown to block several physiological actions of galanin. The present experiments tested the ability of M40 to block the effects of galanin on DNMTP performance. M40 completely blocked choice-accuracy deficits induced by galanin administration in both the lateral ventricle and ventral hippocampus, at doses of M40 approximately 5-fold the molar dose of galanin. M40 appears to be an effective galanin antagonist in a rodent memory paradigm, indicating that this compound may prove useful in investigating the role of endogenous galanin in learning and memory.

Original languageEnglish (US)
Pages (from-to)1025-1032
Number of pages8
JournalBehavioral Neuroscience
Volume110
Issue number5
DOIs
StatePublished - Oct 1996
Externally publishedYes

Fingerprint

Galanin Receptors
Galanin
Aptitude
M40
Lateral Ventricles
Neuropeptides
Short-Term Memory
Acetylcholine
Rodentia
Hippocampus
Learning
Amino Acids

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

Galanin receptor antagonist M40 blocks galanin-induced choice accuracy deficits on a delayed-nonmatching-to-position task. / Mcdonald, Michael; Crawley, Jacqueline N.

In: Behavioral Neuroscience, Vol. 110, No. 5, 10.1996, p. 1025-1032.

Research output: Contribution to journalArticle

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