Ganglioglioma associated with cerebral cortical dysplasia: An unusual case with extensive leptomeningeal involvement

Ali Saad, Mayur Jayarao, Lawrence S. Chin, Ivana Delalle

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ganglioglioma is a tumor occurring in children and young adults and characterized by a superficial cortical location and biphasic histologic differentiation encompassing neuronal and glial elements. Ganglioglioma may arise anywhere throughout the neuraxis, including the optic nerve, brain stem, pineal gland, cerebellum, cerebrum, and spinal cord; however, the majority of glioneuronal neoplasms involve the temporal lobe. Gangliogliomas may show focal leptomeningeal involvement, but predominant leptomeningeal involvement by gangliogliomas is extremely rare; only 2 cases of ganglioglioma extensively involving the leptomeninges have been reported. In this report, we present an unusual case of a ganglioglioma predominantly present within the leptomeninges of a 15-year-old boy with a history of seizures. Furthermore, the cerebral cortex beneath the tumor showed dysplastic changes.We report a very unusual case of ganglioglioma involving predominantly the cerebral leptomeninges and associated with adjacent cerebral cortical dysplasia. Histologic characteristics and diagnostic pitfalls are discussed.

Original languageEnglish (US)
Pages (from-to)474-478
Number of pages5
JournalPediatric and Developmental Pathology
Volume11
Issue number6
DOIs
StatePublished - Nov 1 2008

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Ganglioglioma
Malformations of Cortical Development
Neoplasms
Pineal Gland
Cerebrum
Temporal Lobe
Optic Nerve
Neuroglia
Cerebral Cortex
Cerebellum
Brain Stem
Young Adult
Spinal Cord
Seizures

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

Cite this

Ganglioglioma associated with cerebral cortical dysplasia : An unusual case with extensive leptomeningeal involvement. / Saad, Ali; Jayarao, Mayur; Chin, Lawrence S.; Delalle, Ivana.

In: Pediatric and Developmental Pathology, Vol. 11, No. 6, 01.11.2008, p. 474-478.

Research output: Contribution to journalArticle

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