Gastric mucosal protection by aegle marmelos against gastric mucosal damage

Role of enterochromaffin cell and serotonin

Purnima Singh, Shubha R. Dutta, Debjani Guha

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/Aims: Serotonin (5-hydroxytryptamine; 5-HT) released from enterochromaffin (EC) cells in gastric mucosa inhibits gastric acidity by increasing the gastric mucus secretion. In the present study, we evaluated the effect of aqueous extract of Aegle marmelos (AM) ripe fruit pulp (250 mg/kg body weight) on mean ulcer index (MUI), EC cells, 5-HT content, and adherent mucosal thickness of ulcerated gastric tissue in adult albino rats. Material and Methods: Ulceration was induced by using aspirin (500 mg/kg, p.o.), cerebellar nodular lesion and applying cold-restraint stress. Results: In all cases increased MUI in gastric tissue along with decreased EC cell count was observed with concomitant decrease of 5-HT content and adherent mucosal thickness (P < 0.05). Pretreatment with AM for 14 days decreased MUI, increased EC cell count, and 5-HT content as well as adherent mucosal thickness in all ulcerated group (P < 0.05). Conclusion: AM produces gastric mucosal protection mediated by increased EC cell count and 5-HT levels.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalSaudi Journal of Gastroenterology
Volume21
Issue number1
DOIs
StatePublished - Jan 1 2015

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Aegle
Enterochromaffin Cells
Serotonin
Stomach
Ulcer
Cell Count
Mucus
Gastric Mucosa
Aspirin
Fruit
Body Weight

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Gastric mucosal protection by aegle marmelos against gastric mucosal damage : Role of enterochromaffin cell and serotonin. / Singh, Purnima; Dutta, Shubha R.; Guha, Debjani.

In: Saudi Journal of Gastroenterology, Vol. 21, No. 1, 01.01.2015, p. 35-42.

Research output: Contribution to journalArticle

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