Gastroduodenal ulceration in rabbits producing antibodies to prostaglandins

G. A. Olson, Charles Leffler, A. M. Fletcher

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The consistent occurrence of gastric and duodenal ulcers was observed in laboratory rabbits used for production of high-titer plasma antibody to 6-keto PGF and PGE2. Perforations developed in 7 of 10 animals, usually just distal to the pyloroduodenal junction. The remaining rabbits showed gross and/or microscopic evidence of imperforate ulcers and erosions. These lesions appeared to be direct pathologic complications of an immune response directed against prostaglandins since animals immunized against met-enkephalin with similar methods had no ulcers.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalProstaglandins
Volume29
Issue number3
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

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Ulcer
Prostaglandins
Animals
Rabbits
Methionine Enkephalin
Antibodies
Stomach Ulcer
Duodenal Ulcer
Dinoprostone
Erosion
Plasmas
prostaglandin F1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology

Cite this

Gastroduodenal ulceration in rabbits producing antibodies to prostaglandins. / Olson, G. A.; Leffler, Charles; Fletcher, A. M.

In: Prostaglandins, Vol. 29, No. 3, 01.01.1985, p. 475-480.

Research output: Contribution to journalArticle

Olson, G. A. ; Leffler, Charles ; Fletcher, A. M. / Gastroduodenal ulceration in rabbits producing antibodies to prostaglandins. In: Prostaglandins. 1985 ; Vol. 29, No. 3. pp. 475-480.
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