Gastroparesis following kidney/pancreas transplant

Ann K. Cashion, S. L. Holmes, Donna Hathaway, A. O. Gaber

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This pilot study examined associations among patterns of gastric myoelectrical activity, symptoms of gastroparesis, years of diabetes, months of dialysis, and use of gastrointestinal medications in gastroparetic kidney-pancreas (KP) transplant recipients. Electrogastrography (EGG) and gastric symptom data were obtained from 42 transplant recipients before and after transplant (6, 12, and 24 months). Recipients were 38 ± 7 yr of age, 88% Whites, and 60% male; 97% had hypertension. All had functioning grafts post-transplant (mean creatinine, 1.59 ± 0.66 mg/dL, and serum glucose 91.97 ± 24.92 mg/dL). Sixteen subjects had normal EGG (2.7-3.2 cycles per minute, cpm); two were tachygastric (>3.2 cpm) at all time points; one remained bradygastric (<2.7 cpm) throughout the study period. Following transplant, symptoms lessened and were associated with 6-month normalization of EGG (r = 0.41, p = 0.02). A small change in the percentage of patients with normal EGG was observed from baseline to 24 months (67% vs. 69% respectively); however, there was a shift from bradygastria (29% to 15% respectively) to tachygastria (5% to 15% respectively). Prescribed prokinetic and antisecretory medications use increased over the study period from 13 (31%) subjects at baseline to 32 (86%) at 6 months; 21 (78%) at 12 months; and 12 (92%) at 24 months. Although symptoms diminish following transplant, gastroparesis remains a significant problem for transplant patients. Normalization of EGG and shifts from bradygastria to tachygastria occur post-transplant. Our results suggest that serial EGGs and frequent assessment of symptoms can be used to follow gastroparesis in KP recipients.

Original languageEnglish (US)
Pages (from-to)306-311
Number of pages6
JournalClinical Transplantation
Volume18
Issue number3
DOIs
StatePublished - Jun 2004

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Gastroparesis
Pancreas
Transplants
Kidney
Stomach
Symptom Assessment
Eggs
Dialysis
Creatinine
Hypertension
Glucose
Serum

All Science Journal Classification (ASJC) codes

  • Transplantation
  • Immunology

Cite this

Gastroparesis following kidney/pancreas transplant. / Cashion, Ann K.; Holmes, S. L.; Hathaway, Donna; Gaber, A. O.

In: Clinical Transplantation, Vol. 18, No. 3, 06.2004, p. 306-311.

Research output: Contribution to journalArticle

Cashion, Ann K. ; Holmes, S. L. ; Hathaway, Donna ; Gaber, A. O. / Gastroparesis following kidney/pancreas transplant. In: Clinical Transplantation. 2004 ; Vol. 18, No. 3. pp. 306-311.
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abstract = "This pilot study examined associations among patterns of gastric myoelectrical activity, symptoms of gastroparesis, years of diabetes, months of dialysis, and use of gastrointestinal medications in gastroparetic kidney-pancreas (KP) transplant recipients. Electrogastrography (EGG) and gastric symptom data were obtained from 42 transplant recipients before and after transplant (6, 12, and 24 months). Recipients were 38 ± 7 yr of age, 88{\%} Whites, and 60{\%} male; 97{\%} had hypertension. All had functioning grafts post-transplant (mean creatinine, 1.59 ± 0.66 mg/dL, and serum glucose 91.97 ± 24.92 mg/dL). Sixteen subjects had normal EGG (2.7-3.2 cycles per minute, cpm); two were tachygastric (>3.2 cpm) at all time points; one remained bradygastric (<2.7 cpm) throughout the study period. Following transplant, symptoms lessened and were associated with 6-month normalization of EGG (r = 0.41, p = 0.02). A small change in the percentage of patients with normal EGG was observed from baseline to 24 months (67{\%} vs. 69{\%} respectively); however, there was a shift from bradygastria (29{\%} to 15{\%} respectively) to tachygastria (5{\%} to 15{\%} respectively). Prescribed prokinetic and antisecretory medications use increased over the study period from 13 (31{\%}) subjects at baseline to 32 (86{\%}) at 6 months; 21 (78{\%}) at 12 months; and 12 (92{\%}) at 24 months. Although symptoms diminish following transplant, gastroparesis remains a significant problem for transplant patients. Normalization of EGG and shifts from bradygastria to tachygastria occur post-transplant. Our results suggest that serial EGGs and frequent assessment of symptoms can be used to follow gastroparesis in KP recipients.",
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