GATE validation of standard dual energy corrections in small animal SPECT-CT

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This paper addresses 123I and 125I dual isotope SPECT imaging, which can be challenging because of spectrum overlap in the low energy spectrums of these isotopes. We first quantify the contribution of low-energy photons from each isotope using GATE-based Monte Carlo simulations for the MOBY mouse phantom. We then describe and analyze a simple, but effective method that uses the ratio of detected low and high energy 123I activity to separate the mixed low energy 123I and 125I activities. Performance is compared with correction methods used in conventional tissue biodistribution techniques. The results indicate that the spectrum overlap effects can be significantly reduced, if not entirely eliminated, when attenuation and scatter is either absent or corrected for using standard methods. In particular, we show that relative activity levels of the two isotopes can be accurately estimated for a wide range of organs and provide quantitative validation that standard methods for spectrum overlap correction provide reasonable estimates for reasonable corrections in smallanimal SPECT/CT imaging.

Original languageEnglish (US)
Article numbere122780
JournalPloS one
Volume10
Issue number4
DOIs
StatePublished - Apr 7 2015

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Isotopes
Animals
isotopes
energy
animals
Imaging techniques
image analysis
Single-Photon Emission-Computed Tomography
methodology
Photons
Tissue
Single Photon Emission Computed Tomography Computed Tomography
mice

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

GATE validation of standard dual energy corrections in small animal SPECT-CT. / Lee, Sanghyeb; Gregor, Jens; Kennel, Stephen; Osborne, Dustin; Wall, Jonathan.

In: PloS one, Vol. 10, No. 4, e122780, 07.04.2015.

Research output: Contribution to journalArticle

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