Gender predilection of antibiotic-induced granulocytopenia in outpatients with septic arthritis or osteomyelitis

Inga M. Himelright, Anuwat Keerasuntonpong, Julie A. McReynolds, Edwin A. Smith, Edward A. Abell, Russell Smith, Larry M. Baddour

Research output: Contribution to journalArticle

Abstract

Medical records of 38 patients who experienced 44 episodes of prolonged courses of antibiotics between March 1992 and May 1994 were retrospectively reviewed to define the incidence of granulocytopenia. All patients were being treated for septic arthritis or osteomyelitis (25 males; 13 females). Of the 44 evaluable courses, there were nine episodes of granulocytopenia (23.7%). The mean time to occurrence of granulocytopenia was 25.7 days, and the median was 20 days. The sex distribution of patients developing granulocytopenia was striking. Of the 13 females receiving antibiotics, six developed granulocytopenia (46.2%); only three of the 25 males did (12.0%, P = .0276). In the subset of patients who received vancomycin, four of five females developed granulocytopenia. In contrast, none of the eight males who received vancomycin manifested granulocytopenia (P = .0070). In our population, the timing of granulocytopenia was consistent with previously published data (average, 22 days). Therefore, patients should be closely monitored for the occurrence of granulocytopenia for the duration of antibiotic therapy. Moreover, females may be particularly at risk.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalInfectious Diseases in Clinical Practice
Volume6
Issue number3
DOIs
StatePublished - Jan 1 1997

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Infectious Arthritis
Agranulocytosis
Osteomyelitis
Outpatients
Anti-Bacterial Agents
Vancomycin
Sex Distribution
Medical Records
Incidence

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Gender predilection of antibiotic-induced granulocytopenia in outpatients with septic arthritis or osteomyelitis. / Himelright, Inga M.; Keerasuntonpong, Anuwat; McReynolds, Julie A.; Smith, Edwin A.; Abell, Edward A.; Smith, Russell; Baddour, Larry M.

In: Infectious Diseases in Clinical Practice, Vol. 6, No. 3, 01.01.1997, p. 183-187.

Research output: Contribution to journalArticle

Himelright, Inga M. ; Keerasuntonpong, Anuwat ; McReynolds, Julie A. ; Smith, Edwin A. ; Abell, Edward A. ; Smith, Russell ; Baddour, Larry M. / Gender predilection of antibiotic-induced granulocytopenia in outpatients with septic arthritis or osteomyelitis. In: Infectious Diseases in Clinical Practice. 1997 ; Vol. 6, No. 3. pp. 183-187.
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