Gene-environment interaction involving recently identified colorectal cancer susceptibility loci

Elizabeth D. Kantor, Carolyn M. Hutter, Jessica Minnier, Sonja I. Berndt, Hermann Brenner, Bette J. Caan, Peter T. Campbell, Christopher S. Carlson, Graham Casey, Andrew T. Chan, Jenny Chang-Claude, Stephen J. Chanock, Michelle Cotterchio, Mengmeng Du, David Duggan, Charles S. Fuchs, Edward L. Giovannucci, Jian Gong, Tabitha A. Harrison, Richard B. Hayes & 26 others Brian E. Henderson, Michael Hoffmeister, John L. Hopper, Mark A. Jenkins, Shuo Jiao, Laurence N. Kolonel, Loic Le Marchand, Mathieu Lemire, Jing Ma, Polly A. Newcomb, Heather M. Ochs-Balcom, Bethann M. Pflugeisen, John D. Potter, Anja Rudolph, Robert E. Schoen, Daniela Seminara, Martha L. Slattery, Deanna L. Stelling, Fridtjof Thomas, Mark Thornquist, Cornelia M. Ulrich, Greg S. Warnick, Brent W. Zanke, Ulrike Peters, Li Hsu, Emily White

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.

Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.

Results: None of the permutation-adjusted P values reached statistical significance.

Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.

Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.

Original languageEnglish (US)
Pages (from-to)1824-1833
Number of pages10
JournalCancer Epidemiology Biomarkers and Prevention
Volume23
Issue number9
DOIs
StatePublished - Sep 1 2014

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Gene-Environment Interaction
Colorectal Neoplasms
Single Nucleotide Polymorphism
Colonic Neoplasms
Aspirin
Body Mass Index
Smoking
Hormones
Dietary Calcium
Genetic Loci
Molecular Epidemiology
Genome-Wide Association Study
Dietary Fiber
Genetic Predisposition to Disease
Folic Acid
Alcohol Drinking
Vegetables
Meat
Registries
Fruit

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Kantor, E. D., Hutter, C. M., Minnier, J., Berndt, S. I., Brenner, H., Caan, B. J., ... White, E. (2014). Gene-environment interaction involving recently identified colorectal cancer susceptibility loci. Cancer Epidemiology Biomarkers and Prevention, 23(9), 1824-1833. https://doi.org/10.1158/1055-9965.EPI-14-0062

Gene-environment interaction involving recently identified colorectal cancer susceptibility loci. / Kantor, Elizabeth D.; Hutter, Carolyn M.; Minnier, Jessica; Berndt, Sonja I.; Brenner, Hermann; Caan, Bette J.; Campbell, Peter T.; Carlson, Christopher S.; Casey, Graham; Chan, Andrew T.; Chang-Claude, Jenny; Chanock, Stephen J.; Cotterchio, Michelle; Du, Mengmeng; Duggan, David; Fuchs, Charles S.; Giovannucci, Edward L.; Gong, Jian; Harrison, Tabitha A.; Hayes, Richard B.; Henderson, Brian E.; Hoffmeister, Michael; Hopper, John L.; Jenkins, Mark A.; Jiao, Shuo; Kolonel, Laurence N.; Marchand, Loic Le; Lemire, Mathieu; Ma, Jing; Newcomb, Polly A.; Ochs-Balcom, Heather M.; Pflugeisen, Bethann M.; Potter, John D.; Rudolph, Anja; Schoen, Robert E.; Seminara, Daniela; Slattery, Martha L.; Stelling, Deanna L.; Thomas, Fridtjof; Thornquist, Mark; Ulrich, Cornelia M.; Warnick, Greg S.; Zanke, Brent W.; Peters, Ulrike; Hsu, Li; White, Emily.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 23, No. 9, 01.09.2014, p. 1824-1833.

Research output: Contribution to journalArticle

Kantor, ED, Hutter, CM, Minnier, J, Berndt, SI, Brenner, H, Caan, BJ, Campbell, PT, Carlson, CS, Casey, G, Chan, AT, Chang-Claude, J, Chanock, SJ, Cotterchio, M, Du, M, Duggan, D, Fuchs, CS, Giovannucci, EL, Gong, J, Harrison, TA, Hayes, RB, Henderson, BE, Hoffmeister, M, Hopper, JL, Jenkins, MA, Jiao, S, Kolonel, LN, Marchand, LL, Lemire, M, Ma, J, Newcomb, PA, Ochs-Balcom, HM, Pflugeisen, BM, Potter, JD, Rudolph, A, Schoen, RE, Seminara, D, Slattery, ML, Stelling, DL, Thomas, F, Thornquist, M, Ulrich, CM, Warnick, GS, Zanke, BW, Peters, U, Hsu, L & White, E 2014, 'Gene-environment interaction involving recently identified colorectal cancer susceptibility loci', Cancer Epidemiology Biomarkers and Prevention, vol. 23, no. 9, pp. 1824-1833. https://doi.org/10.1158/1055-9965.EPI-14-0062
Kantor, Elizabeth D. ; Hutter, Carolyn M. ; Minnier, Jessica ; Berndt, Sonja I. ; Brenner, Hermann ; Caan, Bette J. ; Campbell, Peter T. ; Carlson, Christopher S. ; Casey, Graham ; Chan, Andrew T. ; Chang-Claude, Jenny ; Chanock, Stephen J. ; Cotterchio, Michelle ; Du, Mengmeng ; Duggan, David ; Fuchs, Charles S. ; Giovannucci, Edward L. ; Gong, Jian ; Harrison, Tabitha A. ; Hayes, Richard B. ; Henderson, Brian E. ; Hoffmeister, Michael ; Hopper, John L. ; Jenkins, Mark A. ; Jiao, Shuo ; Kolonel, Laurence N. ; Marchand, Loic Le ; Lemire, Mathieu ; Ma, Jing ; Newcomb, Polly A. ; Ochs-Balcom, Heather M. ; Pflugeisen, Bethann M. ; Potter, John D. ; Rudolph, Anja ; Schoen, Robert E. ; Seminara, Daniela ; Slattery, Martha L. ; Stelling, Deanna L. ; Thomas, Fridtjof ; Thornquist, Mark ; Ulrich, Cornelia M. ; Warnick, Greg S. ; Zanke, Brent W. ; Peters, Ulrike ; Hsu, Li ; White, Emily. / Gene-environment interaction involving recently identified colorectal cancer susceptibility loci. In: Cancer Epidemiology Biomarkers and Prevention. 2014 ; Vol. 23, No. 9. pp. 1824-1833.
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abstract = "Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.Results: None of the permutation-adjusted P values reached statistical significance.Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.",
author = "Kantor, {Elizabeth D.} and Hutter, {Carolyn M.} and Jessica Minnier and Berndt, {Sonja I.} and Hermann Brenner and Caan, {Bette J.} and Campbell, {Peter T.} and Carlson, {Christopher S.} and Graham Casey and Chan, {Andrew T.} and Jenny Chang-Claude and Chanock, {Stephen J.} and Michelle Cotterchio and Mengmeng Du and David Duggan and Fuchs, {Charles S.} and Giovannucci, {Edward L.} and Jian Gong and Harrison, {Tabitha A.} and Hayes, {Richard B.} and Henderson, {Brian E.} and Michael Hoffmeister and Hopper, {John L.} and Jenkins, {Mark A.} and Shuo Jiao and Kolonel, {Laurence N.} and Marchand, {Loic Le} and Mathieu Lemire and Jing Ma and Newcomb, {Polly A.} and Ochs-Balcom, {Heather M.} and Pflugeisen, {Bethann M.} and Potter, {John D.} and Anja Rudolph and Schoen, {Robert E.} and Daniela Seminara and Slattery, {Martha L.} and Stelling, {Deanna L.} and Fridtjof Thomas and Mark Thornquist and Ulrich, {Cornelia M.} and Warnick, {Greg S.} and Zanke, {Brent W.} and Ulrike Peters and Li Hsu and Emily White",
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TY - JOUR

T1 - Gene-environment interaction involving recently identified colorectal cancer susceptibility loci

AU - Kantor, Elizabeth D.

AU - Hutter, Carolyn M.

AU - Minnier, Jessica

AU - Berndt, Sonja I.

AU - Brenner, Hermann

AU - Caan, Bette J.

AU - Campbell, Peter T.

AU - Carlson, Christopher S.

AU - Casey, Graham

AU - Chan, Andrew T.

AU - Chang-Claude, Jenny

AU - Chanock, Stephen J.

AU - Cotterchio, Michelle

AU - Du, Mengmeng

AU - Duggan, David

AU - Fuchs, Charles S.

AU - Giovannucci, Edward L.

AU - Gong, Jian

AU - Harrison, Tabitha A.

AU - Hayes, Richard B.

AU - Henderson, Brian E.

AU - Hoffmeister, Michael

AU - Hopper, John L.

AU - Jenkins, Mark A.

AU - Jiao, Shuo

AU - Kolonel, Laurence N.

AU - Marchand, Loic Le

AU - Lemire, Mathieu

AU - Ma, Jing

AU - Newcomb, Polly A.

AU - Ochs-Balcom, Heather M.

AU - Pflugeisen, Bethann M.

AU - Potter, John D.

AU - Rudolph, Anja

AU - Schoen, Robert E.

AU - Seminara, Daniela

AU - Slattery, Martha L.

AU - Stelling, Deanna L.

AU - Thomas, Fridtjof

AU - Thornquist, Mark

AU - Ulrich, Cornelia M.

AU - Warnick, Greg S.

AU - Zanke, Brent W.

AU - Peters, Ulrike

AU - Hsu, Li

AU - White, Emily

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.Results: None of the permutation-adjusted P values reached statistical significance.Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.

AB - Background: Genome-wide association studies have identified several single nucleotide polymorphisms (SNPs) that are associated with risk of colorectal cancer. Prior research has evaluated the presence of gene- environment interaction involving the first 10 identified susceptibility loci, but little work has been conducted on interaction involving SNPs at recently identified susceptibility loci, including: rs10911251, rs6691170, rs6687758, rs11903757, rs10936599, rs647161, rs1321311, rs719725, rs1665650, rs3824999, rs7136702, rs11169552, rs59336, rs3217810, rs4925386, and rs2423279.Methods: Data on 9, 160 cases and 9, 280 controls from the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) and Colon Cancer Family Registry (CCFR) were used to evaluate the presence of interaction involving the above-listed SNPs and sex, body mass index (BMI), alcohol consumption, smoking, aspirin use, postmenopausal hormone (PMH) use, as well as intake of dietary calcium, dietary fiber, dietary folate, red meat, processed meat, fruit, and vegetables. Interaction was evaluated using a fixed effects metaanalysis of an efficient Empirical Bayes estimator, and permutation was used to account for multiple comparisons.Results: None of the permutation-adjusted P values reached statistical significance.Conclusions: The associations between recently identified genetic susceptibility loci and colorectal cancer are not strongly modified by sex, BMI, alcohol, smoking, aspirin, PMH use, and various dietary factors.Impact: Results suggest no evidence of strong gene-environment interactions involving the recently identified 16 susceptibility loci for colorectal cancer taken one at a time.

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DO - 10.1158/1055-9965.EPI-14-0062

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SP - 1824

EP - 1833

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

SN - 1055-9965

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