Gene expression profiling of childhood adrenocortical tumors

Alina West, Geoffrey A. Neale, Stanley Pounds, Bonald C. Figueredo, Carlos Rodriguez Galindo, Mara Albonei D. Pianovski, Antonio G. Oliveira Filho, David Malkin, Enzo Lalli, Raul Ribeiro, Gerard P. Zambetti

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Pediatric adrenocortical tumors (ACT) are rare and often fatal malignancies; little is known regarding their etiology and biology. To provide additional insight into the nature of ACT, we determined the gene expression profiles of 24 pediatric tumors (five adenomas, 18 carcinomas, and one undetermined) and seven normal adrenal glands. Distinct patterns of gene expression, validated by quantitative real-time PCR and Western blot analysis, were identified that distinguish normal adrenal cortex from tumor. Differences in gene expression were also identified between adrenocortical adenomas and carcinomas. In addition, pediatric adrenocortical carcinomas were found to share similar patterns of gene expression when compared with those published for adult ACT. This study represents the first microarray analysis of childhood ACT. Our findings lay the groundwork for establishing gene expression profiles that may aid in the diagnosis and prognosis of pediatric ACT, and in the identification of signaling pathways that contribute to this disease.

Original languageEnglish (US)
Pages (from-to)600-608
Number of pages9
JournalCancer Research
Volume67
Issue number2
DOIs
StatePublished - Jan 15 2007

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Gene Expression Profiling
Neoplasms
Pediatrics
Transcriptome
Gene Expression
Adrenocortical Adenoma
Adrenocortical Carcinoma
Adrenal Cortex
Microarray Analysis
Adrenal Glands
Adenoma
Real-Time Polymerase Chain Reaction
Western Blotting
Carcinoma

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

West, A., Neale, G. A., Pounds, S., Figueredo, B. C., Galindo, C. R., Pianovski, M. A. D., ... Zambetti, G. P. (2007). Gene expression profiling of childhood adrenocortical tumors. Cancer Research, 67(2), 600-608. https://doi.org/10.1158/0008-5472.CAN-06-3767

Gene expression profiling of childhood adrenocortical tumors. / West, Alina; Neale, Geoffrey A.; Pounds, Stanley; Figueredo, Bonald C.; Galindo, Carlos Rodriguez; Pianovski, Mara Albonei D.; Oliveira Filho, Antonio G.; Malkin, David; Lalli, Enzo; Ribeiro, Raul; Zambetti, Gerard P.

In: Cancer Research, Vol. 67, No. 2, 15.01.2007, p. 600-608.

Research output: Contribution to journalArticle

West, A, Neale, GA, Pounds, S, Figueredo, BC, Galindo, CR, Pianovski, MAD, Oliveira Filho, AG, Malkin, D, Lalli, E, Ribeiro, R & Zambetti, GP 2007, 'Gene expression profiling of childhood adrenocortical tumors', Cancer Research, vol. 67, no. 2, pp. 600-608. https://doi.org/10.1158/0008-5472.CAN-06-3767
West A, Neale GA, Pounds S, Figueredo BC, Galindo CR, Pianovski MAD et al. Gene expression profiling of childhood adrenocortical tumors. Cancer Research. 2007 Jan 15;67(2):600-608. https://doi.org/10.1158/0008-5472.CAN-06-3767
West, Alina ; Neale, Geoffrey A. ; Pounds, Stanley ; Figueredo, Bonald C. ; Galindo, Carlos Rodriguez ; Pianovski, Mara Albonei D. ; Oliveira Filho, Antonio G. ; Malkin, David ; Lalli, Enzo ; Ribeiro, Raul ; Zambetti, Gerard P. / Gene expression profiling of childhood adrenocortical tumors. In: Cancer Research. 2007 ; Vol. 67, No. 2. pp. 600-608.
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