Genenetwork: A toolbox for systems genetics

Research output: Chapter in Book/Report/Conference proceedingChapter

26 Citations (Scopus)

Abstract

The goal of systems genetics is to understand the impact of genetic variation across all levels of biological organization, from mRNAs, proteins, and metabolites, to higher-order physiological and behavioral traits. This approach requires the accumulation and integration of many types of data, and also requires the use of many types of statistical tools to extract relevant patterns of covariation and causal relations as a function of genetics, environment, stage, and treatment. In this protocol we explain how to use the GeneNetwork web service, a powerful and free online resource for systems genetics. We provide workflows and methods to navigate massive multiscalar data sets and we explain how to use an extensive systems genetics toolkit for analysis and synthesis. Finally, we provide two detailed case studies that take advantage of human and mouse cohorts to evaluate linkage between gene variants, addiction, and aging.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages75-120
Number of pages46
DOIs
StatePublished - Jan 1 2017

Publication series

NameMethods in Molecular Biology
Volume1488
ISSN (Print)1064-3745

Fingerprint

Online Systems
Workflow
Messenger RNA
Genes
Proteins
Datasets

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

Cite this

Mulligan, M., Mozhui, K., Prins, P., & Williams, R. (2017). Genenetwork: A toolbox for systems genetics. In Methods in Molecular Biology (pp. 75-120). (Methods in Molecular Biology; Vol. 1488). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6427-7_4

Genenetwork : A toolbox for systems genetics. / Mulligan, Megan; Mozhui, Khyobeni; Prins, Pjotr; Williams, Robert.

Methods in Molecular Biology. Humana Press Inc., 2017. p. 75-120 (Methods in Molecular Biology; Vol. 1488).

Research output: Chapter in Book/Report/Conference proceedingChapter

Mulligan, M, Mozhui, K, Prins, P & Williams, R 2017, Genenetwork: A toolbox for systems genetics. in Methods in Molecular Biology. Methods in Molecular Biology, vol. 1488, Humana Press Inc., pp. 75-120. https://doi.org/10.1007/978-1-4939-6427-7_4
Mulligan M, Mozhui K, Prins P, Williams R. Genenetwork: A toolbox for systems genetics. In Methods in Molecular Biology. Humana Press Inc. 2017. p. 75-120. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6427-7_4
Mulligan, Megan ; Mozhui, Khyobeni ; Prins, Pjotr ; Williams, Robert. / Genenetwork : A toolbox for systems genetics. Methods in Molecular Biology. Humana Press Inc., 2017. pp. 75-120 (Methods in Molecular Biology).
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