General nature of the STAT3-activated anti-inflammatory response

Karim C. El Kasmi, Jeff Holst, Maryaline Coffre, Lisa Mielke, Antoine De Pauw, Nouara Lhocine, Amber Smith, Robert Rutschman, Deepak Kaushal, Yuhong Shen, Takashi Suda, Raymond P. Donnelly, Martin G. Myers, Warren Alexander, Dario A.A. Vignali, Stephanie S. Watowich, Matthias Ernst, Douglas J. Hilton, Peter J. Murray

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Although many cytokine receptors generate their signals via the STAT3 pathway, the IL-10R appears unique in promoting a potent anti-inflammatory response (AIR) via STAT3 to antagonize proinflammatory signals that activate the innate immune response. We found that heterologous cytokine receptor systems that activate STAT3 but are naturally refractory (the IL-22R), or engineered to be refractory (the IL-6, leptin, and erythropoietin receptors), to suppressor of cytokine signaling-3-mediated inhibition activate an AIR indistinguishable from IL-10. We conclude that the AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R.

Original languageEnglish (US)
Pages (from-to)7880-7888
Number of pages9
JournalJournal of Immunology
Volume177
Issue number11
DOIs
StatePublished - Dec 1 2006

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Cytokine Receptors
Anti-Inflammatory Agents
Cytokines
Erythropoietin Receptors
Interleukin-6 Receptors
Leptin Receptors
Innate Immunity
Interleukin-10
interleukin-22 receptor

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

El Kasmi, K. C., Holst, J., Coffre, M., Mielke, L., De Pauw, A., Lhocine, N., ... Murray, P. J. (2006). General nature of the STAT3-activated anti-inflammatory response. Journal of Immunology, 177(11), 7880-7888. https://doi.org/10.4049/jimmunol.177.11.7880

General nature of the STAT3-activated anti-inflammatory response. / El Kasmi, Karim C.; Holst, Jeff; Coffre, Maryaline; Mielke, Lisa; De Pauw, Antoine; Lhocine, Nouara; Smith, Amber; Rutschman, Robert; Kaushal, Deepak; Shen, Yuhong; Suda, Takashi; Donnelly, Raymond P.; Myers, Martin G.; Alexander, Warren; Vignali, Dario A.A.; Watowich, Stephanie S.; Ernst, Matthias; Hilton, Douglas J.; Murray, Peter J.

In: Journal of Immunology, Vol. 177, No. 11, 01.12.2006, p. 7880-7888.

Research output: Contribution to journalArticle

El Kasmi, KC, Holst, J, Coffre, M, Mielke, L, De Pauw, A, Lhocine, N, Smith, A, Rutschman, R, Kaushal, D, Shen, Y, Suda, T, Donnelly, RP, Myers, MG, Alexander, W, Vignali, DAA, Watowich, SS, Ernst, M, Hilton, DJ & Murray, PJ 2006, 'General nature of the STAT3-activated anti-inflammatory response', Journal of Immunology, vol. 177, no. 11, pp. 7880-7888. https://doi.org/10.4049/jimmunol.177.11.7880
El Kasmi KC, Holst J, Coffre M, Mielke L, De Pauw A, Lhocine N et al. General nature of the STAT3-activated anti-inflammatory response. Journal of Immunology. 2006 Dec 1;177(11):7880-7888. https://doi.org/10.4049/jimmunol.177.11.7880
El Kasmi, Karim C. ; Holst, Jeff ; Coffre, Maryaline ; Mielke, Lisa ; De Pauw, Antoine ; Lhocine, Nouara ; Smith, Amber ; Rutschman, Robert ; Kaushal, Deepak ; Shen, Yuhong ; Suda, Takashi ; Donnelly, Raymond P. ; Myers, Martin G. ; Alexander, Warren ; Vignali, Dario A.A. ; Watowich, Stephanie S. ; Ernst, Matthias ; Hilton, Douglas J. ; Murray, Peter J. / General nature of the STAT3-activated anti-inflammatory response. In: Journal of Immunology. 2006 ; Vol. 177, No. 11. pp. 7880-7888.
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