Generation of a fibroblast chemotactic factor in serum by activation of complement.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

When serum complement is activated by either the classical or alternative pathways, a factor with an apparent 80,000 mol wt is generated that is chemotactic for human dermal fibroblasts. The origin of this serum-derived chemotactic factor (SDCF) is not known; however, it may be a cleavage product from C5 because it is inactivated by monospecific antiserum to human C5, and it is not generated when the complement system is activated in human serum deficient in C5. SDCF is not chemotactic for human neutrophils or monocytes. Because SDCF is generated when serum complement is activated, it may function in vivo to attract connective tissue fibroblasts to sites of inflammatory reactions in which the complement system participates.

Original languageEnglish (US)
Pages (from-to)1379-1385
Number of pages7
JournalThe Journal of clinical investigation
Volume64
Issue number5
DOIs
StatePublished - Jan 1 1979

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Complement Activation
Chemotactic Factors
Fibroblasts
Serum
Connective Tissue
Immune Sera
Monocytes
Neutrophils
Skin

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Generation of a fibroblast chemotactic factor in serum by activation of complement. / Postlethwaite, Arnold; Snyderman, R.; Kang, Andrew.

In: The Journal of clinical investigation, Vol. 64, No. 5, 01.01.1979, p. 1379-1385.

Research output: Contribution to journalArticle

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