Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

the Million Veteran Program

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.

Original languageEnglish (US)
Pages (from-to)1412-1425
Number of pages14
JournalNature Genetics
Volume50
Issue number10
DOIs
StatePublished - Oct 1 2018

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Blood Pressure
Cardiovascular Diseases
Genetic Association Studies
Life Style
Hypertension

All Science Journal Classification (ASJC) codes

  • Genetics

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Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. / the Million Veteran Program.

In: Nature Genetics, Vol. 50, No. 10, 01.10.2018, p. 1412-1425.

Research output: Contribution to journalArticle

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abstract = "High blood pressure is a highly heritable and modifiable risk factor for cardiovascular disease. We report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry. We identify 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures. Our findings identify new biological pathways for blood pressure regulation with potential for improved cardiovascular disease prevention in the future.",
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