Genetic ancestry-smoking interactions and lung function in African Americans: A cohort Study

Melinda C. Aldrich, Rajesh Kumar, Laura A. Colangelo, L. Keoki Williams, Saunak Sen, Stephen B. Kritchevsky, Bernd Meibohm, Joshua Galanter, Donglei Hu, Christopher R. Gignoux, Yongmei Liu, Tamara B. Harris, Elad Ziv, Joseph Zmuda, Melissa Garcia, Tennille S. Leak, Marilyn G. Foreman, Lewis J. Smith, Myriam Fornage, Kiang LiuEsteban G. Burchard

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. Methodology/Principal Findings: We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (-5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. Conclusions/Significance: African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.

Original languageEnglish (US)
Article numbere39541
JournalPloS one
Volume7
Issue number6
DOIs
StatePublished - Jun 21 2012

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lung function
African Americans
cohort studies
ancestry
Cohort Studies
Smoking
Lung
Tobacco
smoking (habit)
Aging of materials
Body Composition
Health
young adults
Coronary Artery Disease
Young Adult
body composition
Chemical analysis
Metabolism
Smoke
Forced Expiratory Volume

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Aldrich, M. C., Kumar, R., Colangelo, L. A., Williams, L. K., Sen, S., Kritchevsky, S. B., ... Burchard, E. G. (2012). Genetic ancestry-smoking interactions and lung function in African Americans: A cohort Study. PloS one, 7(6), [e39541]. https://doi.org/10.1371/journal.pone.0039541

Genetic ancestry-smoking interactions and lung function in African Americans : A cohort Study. / Aldrich, Melinda C.; Kumar, Rajesh; Colangelo, Laura A.; Williams, L. Keoki; Sen, Saunak; Kritchevsky, Stephen B.; Meibohm, Bernd; Galanter, Joshua; Hu, Donglei; Gignoux, Christopher R.; Liu, Yongmei; Harris, Tamara B.; Ziv, Elad; Zmuda, Joseph; Garcia, Melissa; Leak, Tennille S.; Foreman, Marilyn G.; Smith, Lewis J.; Fornage, Myriam; Liu, Kiang; Burchard, Esteban G.

In: PloS one, Vol. 7, No. 6, e39541, 21.06.2012.

Research output: Contribution to journalArticle

Aldrich, MC, Kumar, R, Colangelo, LA, Williams, LK, Sen, S, Kritchevsky, SB, Meibohm, B, Galanter, J, Hu, D, Gignoux, CR, Liu, Y, Harris, TB, Ziv, E, Zmuda, J, Garcia, M, Leak, TS, Foreman, MG, Smith, LJ, Fornage, M, Liu, K & Burchard, EG 2012, 'Genetic ancestry-smoking interactions and lung function in African Americans: A cohort Study', PloS one, vol. 7, no. 6, e39541. https://doi.org/10.1371/journal.pone.0039541
Aldrich, Melinda C. ; Kumar, Rajesh ; Colangelo, Laura A. ; Williams, L. Keoki ; Sen, Saunak ; Kritchevsky, Stephen B. ; Meibohm, Bernd ; Galanter, Joshua ; Hu, Donglei ; Gignoux, Christopher R. ; Liu, Yongmei ; Harris, Tamara B. ; Ziv, Elad ; Zmuda, Joseph ; Garcia, Melissa ; Leak, Tennille S. ; Foreman, Marilyn G. ; Smith, Lewis J. ; Fornage, Myriam ; Liu, Kiang ; Burchard, Esteban G. / Genetic ancestry-smoking interactions and lung function in African Americans : A cohort Study. In: PloS one. 2012 ; Vol. 7, No. 6.
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abstract = "Background: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. Methodology/Principal Findings: We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (-5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. Conclusions/Significance: African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.",
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T1 - Genetic ancestry-smoking interactions and lung function in African Americans

T2 - A cohort Study

AU - Aldrich, Melinda C.

AU - Kumar, Rajesh

AU - Colangelo, Laura A.

AU - Williams, L. Keoki

AU - Sen, Saunak

AU - Kritchevsky, Stephen B.

AU - Meibohm, Bernd

AU - Galanter, Joshua

AU - Hu, Donglei

AU - Gignoux, Christopher R.

AU - Liu, Yongmei

AU - Harris, Tamara B.

AU - Ziv, Elad

AU - Zmuda, Joseph

AU - Garcia, Melissa

AU - Leak, Tennille S.

AU - Foreman, Marilyn G.

AU - Smith, Lewis J.

AU - Fornage, Myriam

AU - Liu, Kiang

AU - Burchard, Esteban G.

PY - 2012/6/21

Y1 - 2012/6/21

N2 - Background: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. Methodology/Principal Findings: We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (-5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. Conclusions/Significance: African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.

AB - Background: Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans. Methodology/Principal Findings: We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and tobacco smoking exposure were measured at baseline and repeatedly over the follow-up period. Individual genetic ancestry proportions were estimated using ancestry informative markers selected to distinguish European and West African ancestry. African Americans with a high proportion of African ancestry had lower baseline forced expiratory volume in one second (FEV1) per pack-year of smoking (-5.7 ml FEV1/ smoking pack-year) compared with smokers with lower African ancestry (-4.6 ml in FEV1/ smoking pack-year) (interaction P value = 0.17). Longitudinal analyses revealed a suggestive interaction between smoking, and African ancestry on the rate of FEV1 decline in Health ABC and independently replicated in CARDIA. Conclusions/Significance: African American individuals with a high proportion of African ancestry are at greater risk for losing lung function while smoking.

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