Genetic and molecular basis of cardiac arrhythmias

Impact on clinical management parts I and II

Silvia G. Priori, Jacques Barhanin, Richard N.W. Hauer, Wilhelm Haverkamp, Habo J. Jongsma, André G. Kleber, William J. McKenna, Dan M. Roden, Yoram Rudy, Ketty Schwartz, Peter J. Schwartz, Jeffrey Towbin, Arthur M. Wilde

Research output: Contribution to journalArticle

266 Citations (Scopus)

Abstract

Genetic approaches have succeeded in defining the molecular basis of an increasing array of heart diseases. such as hypertrophic cardiomyopathy and the long-QT syndromes, associated with serious arrhythmias. Importantly, the way in which this new knowledge can be applied to managing patients and to the development of syndrome-specific antiarrhythmic strategies is evolving rapidly because of these recent advances. In addition, the extent to which new knowledge represents a purely research tool versus the extent to which it can be applied clinically is also evolving. The present article represents a consensus report of a meeting of the European Working Group on Arrhythmias. The current state of the art of the molecular and genetic basis of inherited arrhythmias is first reviewed, followed by practical advice on the role of genetic testing in these and other syndromes and the way in which new findings have influenced current understanding of the molecular and biophysical basis of arrhythmogenesis.

Original languageEnglish (US)
Pages (from-to)518-528
Number of pages11
JournalCirculation
Volume99
Issue number4
DOIs
StatePublished - Feb 2 1999

Fingerprint

Cardiac Arrhythmias
Molecular Biology
Long QT Syndrome
Hypertrophic Cardiomyopathy
Genetic Testing
Heart Diseases
Research

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Priori, S. G., Barhanin, J., Hauer, R. N. W., Haverkamp, W., Jongsma, H. J., Kleber, A. G., ... Wilde, A. M. (1999). Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II. Circulation, 99(4), 518-528. https://doi.org/10.1161/01.CIR.99.4.518

Genetic and molecular basis of cardiac arrhythmias : Impact on clinical management parts I and II. / Priori, Silvia G.; Barhanin, Jacques; Hauer, Richard N.W.; Haverkamp, Wilhelm; Jongsma, Habo J.; Kleber, André G.; McKenna, William J.; Roden, Dan M.; Rudy, Yoram; Schwartz, Ketty; Schwartz, Peter J.; Towbin, Jeffrey; Wilde, Arthur M.

In: Circulation, Vol. 99, No. 4, 02.02.1999, p. 518-528.

Research output: Contribution to journalArticle

Priori, SG, Barhanin, J, Hauer, RNW, Haverkamp, W, Jongsma, HJ, Kleber, AG, McKenna, WJ, Roden, DM, Rudy, Y, Schwartz, K, Schwartz, PJ, Towbin, J & Wilde, AM 1999, 'Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II', Circulation, vol. 99, no. 4, pp. 518-528. https://doi.org/10.1161/01.CIR.99.4.518
Priori SG, Barhanin J, Hauer RNW, Haverkamp W, Jongsma HJ, Kleber AG et al. Genetic and molecular basis of cardiac arrhythmias: Impact on clinical management parts I and II. Circulation. 1999 Feb 2;99(4):518-528. https://doi.org/10.1161/01.CIR.99.4.518
Priori, Silvia G. ; Barhanin, Jacques ; Hauer, Richard N.W. ; Haverkamp, Wilhelm ; Jongsma, Habo J. ; Kleber, André G. ; McKenna, William J. ; Roden, Dan M. ; Rudy, Yoram ; Schwartz, Ketty ; Schwartz, Peter J. ; Towbin, Jeffrey ; Wilde, Arthur M. / Genetic and molecular basis of cardiac arrhythmias : Impact on clinical management parts I and II. In: Circulation. 1999 ; Vol. 99, No. 4. pp. 518-528.
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