Genetic and molecular basis of QTL of diabetes in mouse: Genes and polymorphisms

Peng Gao, Yan Jiao, Qing Xiong, Cong Yi Wang, Ivan Gerling, Weikuan Gu

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

A systematic study has been conducted of all available reports in PubMed and OMIM (Online Mendelian Inheritance in Man) to examine the genetic and molecular basis of quantitative genetic loci (QTL) of diabetes with the main focus on genes and polymorphisms. The major question is, What can the QTL tell us? Specifically, we want to know whether those genome regions differ from other regions in terms of genes relevant to diabetes. Which genes are within those QTL regions, and, among them, which genes have already been linked to diabetes? whether more polymorphisms have been associated with diabetes in the QTL regions than in the non-QTL regions. Our search revealed a total of 9038 genes from 26 type 1 diabetes QTL, which cover 667,096,006 bp of the mouse genomic sequence. On one hand, a large number of candidate genes are in each of these QTL; on the other hand, we found that some obvious candidate genes of QTL have not yet been investigated. Thus, the comprehensive search of candidate genes for known QTL may provide unexpected benefit for identifying QTL genes for diabetes.

Original languageEnglish (US)
Pages (from-to)324-337
Number of pages14
JournalCurrent Genomics
Volume9
Issue number5
DOIs
StatePublished - Aug 25 2008

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Genetic Loci
Molecular Biology
Genes
Genetic Databases
Type 1 Diabetes Mellitus
PubMed
Genome

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Genetic and molecular basis of QTL of diabetes in mouse : Genes and polymorphisms. / Gao, Peng; Jiao, Yan; Xiong, Qing; Wang, Cong Yi; Gerling, Ivan; Gu, Weikuan.

In: Current Genomics, Vol. 9, No. 5, 25.08.2008, p. 324-337.

Research output: Contribution to journalReview article

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