Genetic-based differences in neurotensin levels and receptors in brains of LS × SS mice

V. Gene Erwin, Richard Radcliffe, Beth Hinkle, Byron Jones

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Levels of endogenous neurotensin (NT-IR) in the LS × SS RI strains differed by 3.0-, 4.7-, 5.4-, and 6.9-fold in the ventral midbrain (VMB), hypothalamus (HY), nucleus accumbens (NA), and caudate putamen (CP), respectively. Frequency distributions and estimates of the number of genes indicate that differences in NT-IR are polygenically influenced. The NT-IR levels in NA and CP were significantly correlated, but levels in the VMB did not correlate with those in the NA or CP. Specific binding to either low (NTL)- or high (NTH)-affinity receptors as measured in the absence or presence of levocabastine differed significantly in brain regions from among LS × SS mouse strains. Results indicate a polygenic influence mediating the differences in receptor densities and suggest differences in genetic regulation of NTL and NTH receptors.

Original languageEnglish (US)
Pages (from-to)821-828
Number of pages8
JournalPeptides
Volume14
Issue number4
DOIs
StatePublished - Jan 1 1993

Fingerprint

Neurotensin Receptors
Neurotensin
levocabastine
Putamen
Nucleus Accumbens
Brain
Mesencephalon
Genes
Hypothalamus

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Genetic-based differences in neurotensin levels and receptors in brains of LS × SS mice. / Gene Erwin, V.; Radcliffe, Richard; Hinkle, Beth; Jones, Byron.

In: Peptides, Vol. 14, No. 4, 01.01.1993, p. 821-828.

Research output: Contribution to journalArticle

Gene Erwin, V. ; Radcliffe, Richard ; Hinkle, Beth ; Jones, Byron. / Genetic-based differences in neurotensin levels and receptors in brains of LS × SS mice. In: Peptides. 1993 ; Vol. 14, No. 4. pp. 821-828.
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