Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

Qiuyun Chen, Glenn E. Kirsch, Danmei Zhang, Ramon Brugada, Josep Brugada, Pedro Brugada, Domenico Potenza, Angel Moya, Martin Borggrefe, Günter Breithardt, Rocio Ortiz-Lopez, Zhiqing Wang, Charles Antzelevitch, Richard E. O'Brlen, Eric Schulze-Bahr, Mark T. Keating, Jeffrey Towbin, Qing Wang

Research output: Contribution to journalArticle

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Abstract

Ventricular fibrillation causes more than 300,000 sudden deaths each year in the USA alone. In approximately 5-12% of these cases, there are no demonstrable cardiac or non-cardiac causes to account for the episode, which is therefore classified as idiopathic ventricular fibrillation (IVF). A distinct group of IVF patients has been found to present with a characteristic electrocardiographic pattern. Because of the small size of most pedigrees and the high incidence of sudden death, however, molecular genetic studies of IVF have not yet been done. Because IVF causes cardiac rhythm disturbance, we investigated whether malfunction of ion channels could cause the disorder by studying mutations in the cardiac sodium channel gene SCN5A. We have now identified a missense mutation, a splice-donor mutation, and a frameshift mutation in the coding region of SCN5A in three IVF families. We show that sodium channels with the missense mutation recover from inactivation more rapidly than normal and that the frameshift mutation causes the sodium channel to be non-functional. Our results indicate that mutations in cardiac ion-channel genes contribute to the risk of developing IVF.

Original languageEnglish (US)
Pages (from-to)293-296
Number of pages4
JournalNature
Volume392
Issue number6673
DOIs
StatePublished - Mar 19 1998
Externally publishedYes

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Molecular Biology
Sodium Channels
Frameshift Mutation
Missense Mutation
Sudden Death
Ion Channels
Mutation
Ventricular Fibrillation
Pedigree
Genes
Paroxysmal ventricular fibrillation
Tissue Donors
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • General

Cite this

Chen, Q., Kirsch, G. E., Zhang, D., Brugada, R., Brugada, J., Brugada, P., ... Wang, Q. (1998). Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature, 392(6673), 293-296. https://doi.org/10.1038/32675

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. / Chen, Qiuyun; Kirsch, Glenn E.; Zhang, Danmei; Brugada, Ramon; Brugada, Josep; Brugada, Pedro; Potenza, Domenico; Moya, Angel; Borggrefe, Martin; Breithardt, Günter; Ortiz-Lopez, Rocio; Wang, Zhiqing; Antzelevitch, Charles; O'Brlen, Richard E.; Schulze-Bahr, Eric; Keating, Mark T.; Towbin, Jeffrey; Wang, Qing.

In: Nature, Vol. 392, No. 6673, 19.03.1998, p. 293-296.

Research output: Contribution to journalArticle

Chen, Q, Kirsch, GE, Zhang, D, Brugada, R, Brugada, J, Brugada, P, Potenza, D, Moya, A, Borggrefe, M, Breithardt, G, Ortiz-Lopez, R, Wang, Z, Antzelevitch, C, O'Brlen, RE, Schulze-Bahr, E, Keating, MT, Towbin, J & Wang, Q 1998, 'Genetic basis and molecular mechanism for idiopathic ventricular fibrillation', Nature, vol. 392, no. 6673, pp. 293-296. https://doi.org/10.1038/32675
Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P et al. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998 Mar 19;392(6673):293-296. https://doi.org/10.1038/32675
Chen, Qiuyun ; Kirsch, Glenn E. ; Zhang, Danmei ; Brugada, Ramon ; Brugada, Josep ; Brugada, Pedro ; Potenza, Domenico ; Moya, Angel ; Borggrefe, Martin ; Breithardt, Günter ; Ortiz-Lopez, Rocio ; Wang, Zhiqing ; Antzelevitch, Charles ; O'Brlen, Richard E. ; Schulze-Bahr, Eric ; Keating, Mark T. ; Towbin, Jeffrey ; Wang, Qing. / Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. In: Nature. 1998 ; Vol. 392, No. 6673. pp. 293-296.
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AU - O'Brlen, Richard E.

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AU - Keating, Mark T.

AU - Towbin, Jeffrey

AU - Wang, Qing

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