Genetic control of the rate of wound healing in mice

Xinmin Li, Weikuan Gu, Godfred Masinde, Melanie Hamilton-Ulland, Shizhong Xu, Subburaman Mohan, David J. Baylink

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

There have been few studies of the inheritance of wound healing in mammals. In this study, we demonstrate that inbred strains of mice differ significantly in the rate of wound healing. Of the 20 strains tested, fast healers (MRL/MpJ-FasIpr and LG/J) healed wounds four times faster than slow healers (Balb/cByJ and SJL/J). The genetic basis underlying the difference in the healing capacity was analysed using F2 populations of two different crosses. We show that the wound healing is a polygenically determined quantitative trait with an average estimated heritability of 86%. The modes of gene action in these two crosses are different. In the (MRL/MpJ × SJL/J) cross, genes regulating fast healing in MRL/MpJ mice exhibited additive effects, whereas these effects were suppressed by a dominant repressor gene in CBA/J mice in the (MRL/MpJ-FasIpr × CBA/J) cross. Information gained from this investigation provides insight into further study of molecular mechanisms underlying the rate of wound healing in mammals.

Original languageEnglish (US)
Pages (from-to)668-674
Number of pages7
JournalHeredity
Volume86
Issue number6
DOIs
StatePublished - Oct 16 2001
Externally publishedYes

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Wound Healing
Mammals
Dominant Genes
Inbred CBA Mouse
Inbred Strains Mice
Genes
Wounds and Injuries
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Li, X., Gu, W., Masinde, G., Hamilton-Ulland, M., Xu, S., Mohan, S., & Baylink, D. J. (2001). Genetic control of the rate of wound healing in mice. Heredity, 86(6), 668-674. https://doi.org/10.1046/j.1365-2540.2001.00879.x

Genetic control of the rate of wound healing in mice. / Li, Xinmin; Gu, Weikuan; Masinde, Godfred; Hamilton-Ulland, Melanie; Xu, Shizhong; Mohan, Subburaman; Baylink, David J.

In: Heredity, Vol. 86, No. 6, 16.10.2001, p. 668-674.

Research output: Contribution to journalArticle

Li, X, Gu, W, Masinde, G, Hamilton-Ulland, M, Xu, S, Mohan, S & Baylink, DJ 2001, 'Genetic control of the rate of wound healing in mice', Heredity, vol. 86, no. 6, pp. 668-674. https://doi.org/10.1046/j.1365-2540.2001.00879.x
Li X, Gu W, Masinde G, Hamilton-Ulland M, Xu S, Mohan S et al. Genetic control of the rate of wound healing in mice. Heredity. 2001 Oct 16;86(6):668-674. https://doi.org/10.1046/j.1365-2540.2001.00879.x
Li, Xinmin ; Gu, Weikuan ; Masinde, Godfred ; Hamilton-Ulland, Melanie ; Xu, Shizhong ; Mohan, Subburaman ; Baylink, David J. / Genetic control of the rate of wound healing in mice. In: Heredity. 2001 ; Vol. 86, No. 6. pp. 668-674.
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