Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

Russell L. McLaughlin, Dick Schijven, Wouter Van Rheenen, Kristel R. Van Eijk, Margaret O'Brien, René S. Kahn, Roel A. Ophoff, An Goris, Daniel G. Bradley, Ammar Al-Chalabi, Leonard H. Van Den Berg, Jurjen J. Luykx, Orla Hardiman, Jan H. Veldink, Aleksey Shatunov, Annelot M. Dekker, Frank P. Diekstra, Sara L. Pulit, Rick A.A. Van Der Spek, Perry T.C. Van Doormaal & 416 others William Sproviero, Ashley R. Jones, Garth A. Nicholson, Dominic B. Rowe, Roger Pamphlett, Matthew C. Kiernan, Denis Bauer, Tim Kahlke, Kelly Williams, Filip Eftimov, Isabella Fogh, Nicola Ticozzi, Kuang Lin, Stephanie Millecamps, Francois Salachas, Vincent Meininger, Mamede De Carvalho, Susana Pinto, Jesus S. Mora, Ricardo Rojas-Garcyá, Meraida Polak, Siddharthan Chandran, Shuna Colville, Robert Swingler, Karen E. Morrison, Pamela J. Shaw, John Hardy, Richard W. Orrell, Alan Pittman, Katie Sidle, Pietro Fratta, Andrea Malaspina, Susanne Petri, Susanna Abdulla, Carsten Drepper, Michael Sendtner, Thomas Meyer, Martina Wiedau-Pazos, Catherine Lomen-Hoerth, Vivianna M.Van Deerlin, John Q. Trojanowski, Lauren Elman, Leo McCluskey, Nazli Basak, Thomas Meitinger, Peter Lichtner, Milena Blagojevic-Radivojkov, Christian R. Andres, Cindy Maurel, Gilbert Bensimon, Bernhard Landwehrmeyer, Alexis Brice, Christine A.M. Payan, Safa Saker-Delye, Alexandra Durr, Nicholas Wood, Lukas Tittmann, Wolfgang Lieb, Andre Franke, Marcella Rietschel, Sven Cichon, Markus M. Nothen, Philippe Amouyel, Christophe Tzourio, Jean Francois Dartigues, Andre G. Uitterlinden, Fernando Rivadeneira, Karol Estrada, Albert Hofman, Charles Curtis, Anneke J.Van Derkooi, Marianne De Visser, Markus Weber, Christopher E. Shaw, Bradley N. Smith, Orietta Pansarasa, Cristina Cereda, Roberto Del Bo, Giacomo P. Comi, Sandra D'Alfonso, Cinzia Bertolin, Gianni Soraru, Letizia Mazzini, Viviana Pensato, Cinzia Gellera, Cinzia Tiloca, Antonia Ratti, Andrea Calvo, Cristina Moglia, Maura Brunetti, Simon Arcuti, Rosa Capozzo, Chiara Zecca, Christian Lunetta, Silvana Penco, Nilo Riva, Alessandro Padovani, Massimiliano Filosto, Ian Blair, P. Nigel Leigh, Federico Casale, Adriano Chio, Ettore Beghi, Elisabetta Pupillo, Rosanna Tortelli, Giancarlo Logroscino, John Powell, Albert C. Ludolph, Jochen H. Weishaupt, Wim Robberecht, Philip Van Damme, Robert H. Brown, Jonathan Glass, John E. Landers, Peter M. Andersen, Philippe Corcia, Patrick Vourc'H, Vincenzo Silani, Michael A.Van Es, R. Jeroen Pasterkamp, Cathryn M. Lewis, Gerome Breen, Stephan Ripke, Benjamin M. Neale, Aiden Corvin, James T.R. Walters, Kai How Farh, Peter A. Holmans, Phil Lee, Brendan Bulik-Sullivan, David A. Collier, Hailiang Huang, Tune H. Pers, Ingrid Agartz, Esben Agerbo, Margot Albus, Madeline Alexander, Farooq Amin, Silviu A. Bacanu, Martin Begemann, Richard A. Belliveau, Judit Bene, Sarah E. Bergen, Elizabeth Bevilacqua, Tim B. Bigdeli, Donald W. Black, Richard Bruggeman, Nancy G. Buccola, Randy L. Buckner, William Byerley, Wiepke Cahn, Guiqing Cai, Dominique Campion, Rita M. Cantor, Vaughan J. Carr, Noa Carrera, Stanley V. Catts, Kimberley D. Chambert, Raymond C.K. Chan, Ronald Y.L. Chan, Eric Y.H. Chen, Wei Cheng, Eric F.C. Cheung, Siow Ann Chong, C. Robert Cloninger, David Cohen, Nadine Cohen, Paul Cormican, Nick Craddock, James J. Crowley, David Curtis, Michael Davidson, Kenneth L. Davis, Franziska Degenhardt, Jurgen Del Favero, Ditte Demontis, Dimitris Dikeos, Timothy Dinan, Srdjan Djurovic, Gary Donohoe, Elodie Drapeau, Jubao Duan, Frank Dudbridge, Naser Durmishi, Peter Eichhammer, Johan Eriksson, Valentina Escott-Price, Laurent Essioux, Ayman H. Fanous, Martilias S. Farrell, Josef Frank, Lude Franke, Robert Freedman, Nelson B. Freimer, Marion Friedl, Joseph I. Friedman, Menachem Fromer, Giulio Genovese, Lyudmila Georgieva, Ina Giegling, Paola Giusti-Rodrýguez, Stephanie Godard, Jacqueline I. Goldstein, Vera Golimbet, Srihari Gopal, Jacob Gratten, Lieuwe De Haan, Christian Hammer, Marian L. Hamshere, Mark Hansen, Thomas Hansen, Vahram Haroutunian, Annette M. Hartmann, Frans A. Henskens, Stefan Herms, Joel N. Hirschhorn, Per Hoffmann, Andrea Hofman, Mads V. Hollegaard, David M. Hougaard, Masashi Ikeda, Inge Joa, Antonio Julia, Luba Kalaydjieva, Sena Karachanak-Yankova, Juha Karjalainen, David Kavanagh, Matthew C. Keller, James L. Kennedy, Andrey Khrunin, Yunjung Kim, Janis Klovins, James A. Knowles, Bettina Konte, Vaidutis Kucinskas, Zita Ausrele Kucinskiene, Hana Kuzelova-Ptackova, Anna K. Kahler, Claudine Laurent, Jimmy Lee, S. Hong Lee, Sophie E. Legge, Bernard Lerer, Miaoxin Li, Tao Li, Kung Yee Liang, Jeffrey Lieberman, Svetlana Limborska, Carmel M. Loughland, Jan Lubinski, Jouko Lonnqvist, Milan MacEk, Patrik K.E. Magnusson, Brion S. Maher, Wolfgang Maier, Jacques Mallet, Sara Marsal, Manuel Mattheisen, Morten Mattingsdal, Robert W. McCarley, Colm McDonald, Andrew M. McIntosh, Sandra Meier, Carin J. Meijer, Bela Melegh, Ingrid Melle, Raquelle I. Mesholam-Gately, Andres Metspalu, Patricia T. Michie, Lili Milani, Vihra Milanova, Younes Mokrab, Derek W. Morris, Ole Mors, Kieran C. Murphy, Robin M. Murray, Inez Myin-Germeys, Bertram Muller-Myhsok, Mari Nelis, Igor Nenadic, Deborah A. Nertney, Gerald Nestadt, Kristin K. Nicodemus, Liene Nikitina-Zake, Laura Nisenbaum, Annelie Nordin, Eadbhard O'Callaghan, Colm O'Dushlaine, F. Anthony O'Neill, Sang Yun Oh, Ann Olincy, Line Olsen, Jim Vanos, Christos Pantelis, George N. Papadimitriou, Sergi Papiol, Elena Parkhomenko, Michele T. Pato, Tiina Paunio, Milica Pejovic-Milovancevic, Diana O. Perkins, Olli Pietilainen, Jonathan Pimm, Andrew J. Pocklington, Alkes Price, Ann E. Pulver, Shaun M. Purcell, Digby Quested, Henrik B. Rasmussen, Abraham Reichenberg, Mark A. Reimers, Alexander L. Richards, Joshua L. Roffman, Panos Roussos, Douglas M. Ruderfer, Veikko Salomaa, Alan R. Sanders, Ulrich Schall, Christian R. Schubert, Thomas G. Schulze, Sibylle G. Schwab, Edward M. Scolnick, Rodney J. Scott, Larry J. Seidman, Jianxin Shi, Engilbert Sigurdsson, Teimuraz Silagadze, Jeremy M. Silverman, Kang Sim, Petr Slominsky, Jordan W. Smoller, Hon Cheong So, Chris C.A. Spencer, Eli A. Stah, Hreinn Stefansson, Stacy Steinberg, Elisabeth Stogmann, Richard E. Straub, Eric Strengman, Jana Strohmaier, T. Scott Stroup, Mythily Subramaniam, Jaana Suvisaari, Dragan M. Svrakic, Jin P. Szatkiewicz, Erik Söderman, Srinivas Thirumalai, Draga Toncheva, Sarah Tosato, Juha Veijola, John Waddington, Dermot Walsh, Dai Wang, Qiang Wang, Bradley T. Webb, Mark Weiser, Dieter B. Wildenauer, Nigel M. Williams, Stephanie Williams, Stephanie H. Witt, Aaron Wolen, Emily H.M. Wong, Brandon K. Wormley, Hualin Simon Xi, Clement C. Zai, Xuebin Zheng, Fritz Zimprich, Naomi R. Wray, Kari Stefansson, Peter M. Visscher, Rolf Adolfsson, Ole A. Andreassen, Douglas H.R. Blackwood, Elvira Bramon, Joseph D. Buxbaum, Anders D. Børglum, Ariel Darvasi, Enrico Domenici, Hannelore Ehrenreich, Tonu Esko, Pablo V. Gejman, Michael Gil, Hugh Gurling, Christina M. Hultman, Nakao Iwata, Assen V. Jablensky, Erik G. Jonsson, Kenneth S. Kendler, George Kirov, Jo Knight, Todd Lencz, Douglas F. Levinson, Qingqin S. Li, Jianjun Liu, Anil K. Malhotra, Steven A. McCarrol, Andrew McQuillin, Jennifer L. Moran, Preben B. Mortensen, Bryan J. Mowry, Michael J. Owen, Aarno Palotie, Carlos N. Pato, Tracey L. Petryshen, Danielle Posthuma, Brien P. Riley, Dan Rujescu, Pak C. Sham, Pamela Sklar, David St Clair, Daniel R. Weinberger, Jens R. Wendland, Thomas Werge, Mark J. Daly, Patrick F. Sullivan, Michael C. O'Donovan

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

Original languageEnglish (US)
Article number14774
JournalNature communications
Volume8
DOIs
StatePublished - Mar 21 2017

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schizophrenia
Amyotrophic Lateral Sclerosis
Schizophrenia
Genes
genome
loci
linkages
Genome-Wide Association Study
Linkage Disequilibrium
regression analysis
Comorbidity
disorders
Odds Ratio
estimates

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

McLaughlin, R. L., Schijven, D., Van Rheenen, W., Van Eijk, K. R., O'Brien, M., Kahn, R. S., ... O'Donovan, M. C. (2017). Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature communications, 8, [14774]. https://doi.org/10.1038/ncomms14774

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. / McLaughlin, Russell L.; Schijven, Dick; Van Rheenen, Wouter; Van Eijk, Kristel R.; O'Brien, Margaret; Kahn, René S.; Ophoff, Roel A.; Goris, An; Bradley, Daniel G.; Al-Chalabi, Ammar; Van Den Berg, Leonard H.; Luykx, Jurjen J.; Hardiman, Orla; Veldink, Jan H.; Shatunov, Aleksey; Dekker, Annelot M.; Diekstra, Frank P.; Pulit, Sara L.; Van Der Spek, Rick A.A.; Van Doormaal, Perry T.C.; Sproviero, William; Jones, Ashley R.; Nicholson, Garth A.; Rowe, Dominic B.; Pamphlett, Roger; Kiernan, Matthew C.; Bauer, Denis; Kahlke, Tim; Williams, Kelly; Eftimov, Filip; Fogh, Isabella; Ticozzi, Nicola; Lin, Kuang; Millecamps, Stephanie; Salachas, Francois; Meininger, Vincent; Carvalho, Mamede De; Pinto, Susana; Mora, Jesus S.; Rojas-Garcyá, Ricardo; Polak, Meraida; Chandran, Siddharthan; Colville, Shuna; Swingler, Robert; Morrison, Karen E.; Shaw, Pamela J.; Hardy, John; Orrell, Richard W.; Pittman, Alan; Sidle, Katie; Fratta, Pietro; Malaspina, Andrea; Petri, Susanne; Abdulla, Susanna; Drepper, Carsten; Sendtner, Michael; Meyer, Thomas; Wiedau-Pazos, Martina; Lomen-Hoerth, Catherine; Deerlin, Vivianna M.Van; Trojanowski, John Q.; Elman, Lauren; McCluskey, Leo; Basak, Nazli; Meitinger, Thomas; Lichtner, Peter; Blagojevic-Radivojkov, Milena; Andres, Christian R.; Maurel, Cindy; Bensimon, Gilbert; Landwehrmeyer, Bernhard; Brice, Alexis; Payan, Christine A.M.; Saker-Delye, Safa; Durr, Alexandra; Wood, Nicholas; Tittmann, Lukas; Lieb, Wolfgang; Franke, Andre; Rietschel, Marcella; Cichon, Sven; Nothen, Markus M.; Amouyel, Philippe; Tzourio, Christophe; Dartigues, Jean Francois; Uitterlinden, Andre G.; Rivadeneira, Fernando; Estrada, Karol; Hofman, Albert; Curtis, Charles; Derkooi, Anneke J.Van; De Visser, Marianne; Weber, Markus; Shaw, Christopher E.; Smith, Bradley N.; Pansarasa, Orietta; Cereda, Cristina; Bo, Roberto Del; Comi, Giacomo P.; D'Alfonso, Sandra; Bertolin, Cinzia; Soraru, Gianni; Mazzini, Letizia; Pensato, Viviana; Gellera, Cinzia; Tiloca, Cinzia; Ratti, Antonia; Calvo, Andrea; Moglia, Cristina; Brunetti, Maura; Arcuti, Simon; Capozzo, Rosa; Zecca, Chiara; Lunetta, Christian; Penco, Silvana; Riva, Nilo; Padovani, Alessandro; Filosto, Massimiliano; Blair, Ian; Nigel Leigh, P.; Casale, Federico; Chio, Adriano; Beghi, Ettore; Pupillo, Elisabetta; Tortelli, Rosanna; Logroscino, Giancarlo; Powell, John; Ludolph, Albert C.; Weishaupt, Jochen H.; Robberecht, Wim; Damme, Philip Van; Brown, Robert H.; Glass, Jonathan; Landers, John E.; Andersen, Peter M.; Corcia, Philippe; Vourc'H, Patrick; Silani, Vincenzo; Es, Michael A.Van; Pasterkamp, R. Jeroen; Lewis, Cathryn M.; Breen, Gerome; Ripke, Stephan; Neale, Benjamin M.; Corvin, Aiden; Walters, James T.R.; Farh, Kai How; Holmans, Peter A.; Lee, Phil; Bulik-Sullivan, Brendan; Collier, David A.; Huang, Hailiang; Pers, Tune H.; Agartz, Ingrid; Agerbo, Esben; Albus, Margot; Alexander, Madeline; Amin, Farooq; Bacanu, Silviu A.; Begemann, Martin; Belliveau, Richard A.; Bene, Judit; Bergen, Sarah E.; Bevilacqua, Elizabeth; Bigdeli, Tim B.; Black, Donald W.; Bruggeman, Richard; Buccola, Nancy G.; Buckner, Randy L.; Byerley, William; Cahn, Wiepke; Cai, Guiqing; Campion, Dominique; Cantor, Rita M.; Carr, Vaughan J.; Carrera, Noa; Catts, Stanley V.; Chambert, Kimberley D.; Chan, Raymond C.K.; Chan, Ronald Y.L.; Chen, Eric Y.H.; Cheng, Wei; Cheung, Eric F.C.; Chong, Siow Ann; Cloninger, C. Robert; Cohen, David; Cohen, Nadine; Cormican, Paul; Craddock, Nick; Crowley, James J.; Curtis, David; Davidson, Michael; Davis, Kenneth L.; Degenhardt, Franziska; Favero, Jurgen Del; Demontis, Ditte; Dikeos, Dimitris; Dinan, Timothy; Djurovic, Srdjan; Donohoe, Gary; Drapeau, Elodie; Duan, Jubao; Dudbridge, Frank; Durmishi, Naser; Eichhammer, Peter; Eriksson, Johan; Escott-Price, Valentina; Essioux, Laurent; Fanous, Ayman H.; Farrell, Martilias S.; Frank, Josef; Franke, Lude; Freedman, Robert; Freimer, Nelson B.; Friedl, Marion; Friedman, Joseph I.; Fromer, Menachem; Genovese, Giulio; Georgieva, Lyudmila; Giegling, Ina; Giusti-Rodrýguez, Paola; Godard, Stephanie; Goldstein, Jacqueline I.; Golimbet, Vera; Gopal, Srihari; Gratten, Jacob; De Haan, Lieuwe; Hammer, Christian; Hamshere, Marian L.; Hansen, Mark; Hansen, Thomas; Haroutunian, Vahram; Hartmann, Annette M.; Henskens, Frans A.; Herms, Stefan; Hirschhorn, Joel N.; Hoffmann, Per; Hofman, Andrea; Hollegaard, Mads V.; Hougaard, David M.; Ikeda, Masashi; Joa, Inge; Julia, Antonio; Kalaydjieva, Luba; Karachanak-Yankova, Sena; Karjalainen, Juha; Kavanagh, David; Keller, Matthew C.; Kennedy, James L.; Khrunin, Andrey; Kim, Yunjung; Klovins, Janis; Knowles, James A.; Konte, Bettina; Kucinskas, Vaidutis; Kucinskiene, Zita Ausrele; Kuzelova-Ptackova, Hana; Kahler, Anna K.; Laurent, Claudine; Lee, Jimmy; Hong Lee, S.; Legge, Sophie E.; Lerer, Bernard; Li, Miaoxin; Li, Tao; Liang, Kung Yee; Lieberman, Jeffrey; Limborska, Svetlana; Loughland, Carmel M.; Lubinski, Jan; Lonnqvist, Jouko; MacEk, Milan; Magnusson, Patrik K.E.; Maher, Brion S.; Maier, Wolfgang; Mallet, Jacques; Marsal, Sara; Mattheisen, Manuel; Mattingsdal, Morten; McCarley, Robert W.; McDonald, Colm; McIntosh, Andrew M.; Meier, Sandra; Meijer, Carin J.; Melegh, Bela; Melle, Ingrid; Mesholam-Gately, Raquelle I.; Metspalu, Andres; Michie, Patricia T.; Milani, Lili; Milanova, Vihra; Mokrab, Younes; Morris, Derek W.; Mors, Ole; Murphy, Kieran C.; Murray, Robin M.; Myin-Germeys, Inez; Muller-Myhsok, Bertram; Nelis, Mari; Nenadic, Igor; Nertney, Deborah A.; Nestadt, Gerald; Nicodemus, Kristin K.; Nikitina-Zake, Liene; Nisenbaum, Laura; Nordin, Annelie; O'Callaghan, Eadbhard; O'Dushlaine, Colm; Anthony O'Neill, F.; Oh, Sang Yun; Olincy, Ann; Olsen, Line; Vanos, Jim; Pantelis, Christos; Papadimitriou, George N.; Papiol, Sergi; Parkhomenko, Elena; Pato, Michele T.; Paunio, Tiina; Pejovic-Milovancevic, Milica; Perkins, Diana O.; Pietilainen, Olli; Pimm, Jonathan; Pocklington, Andrew J.; Price, Alkes; Pulver, Ann E.; Purcell, Shaun M.; Quested, Digby; Rasmussen, Henrik B.; Reichenberg, Abraham; Reimers, Mark A.; Richards, Alexander L.; Roffman, Joshua L.; Roussos, Panos; Ruderfer, Douglas M.; Salomaa, Veikko; Sanders, Alan R.; Schall, Ulrich; Schubert, Christian R.; Schulze, Thomas G.; Schwab, Sibylle G.; Scolnick, Edward M.; Scott, Rodney J.; Seidman, Larry J.; Shi, Jianxin; Sigurdsson, Engilbert; Silagadze, Teimuraz; Silverman, Jeremy M.; Sim, Kang; Slominsky, Petr; Smoller, Jordan W.; So, Hon Cheong; Spencer, Chris C.A.; Stah, Eli A.; Stefansson, Hreinn; Steinberg, Stacy; Stogmann, Elisabeth; Straub, Richard E.; Strengman, Eric; Strohmaier, Jana; Scott Stroup, T.; Subramaniam, Mythily; Suvisaari, Jaana; Svrakic, Dragan M.; Szatkiewicz, Jin P.; Söderman, Erik; Thirumalai, Srinivas; Toncheva, Draga; Tosato, Sarah; Veijola, Juha; Waddington, John; Walsh, Dermot; Wang, Dai; Wang, Qiang; Webb, Bradley T.; Weiser, Mark; Wildenauer, Dieter B.; Williams, Nigel M.; Williams, Stephanie; Witt, Stephanie H.; Wolen, Aaron; Wong, Emily H.M.; Wormley, Brandon K.; Xi, Hualin Simon; Zai, Clement C.; Zheng, Xuebin; Zimprich, Fritz; Wray, Naomi R.; Stefansson, Kari; Visscher, Peter M.; Adolfsson, Rolf; Andreassen, Ole A.; Blackwood, Douglas H.R.; Bramon, Elvira; Buxbaum, Joseph D.; Børglum, Anders D.; Darvasi, Ariel; Domenici, Enrico; Ehrenreich, Hannelore; Esko, Tonu; Gejman, Pablo V.; Gil, Michael; Gurling, Hugh; Hultman, Christina M.; Iwata, Nakao; Jablensky, Assen V.; Jonsson, Erik G.; Kendler, Kenneth S.; Kirov, George; Knight, Jo; Lencz, Todd; Levinson, Douglas F.; Li, Qingqin S.; Liu, Jianjun; Malhotra, Anil K.; McCarrol, Steven A.; McQuillin, Andrew; Moran, Jennifer L.; Mortensen, Preben B.; Mowry, Bryan J.; Owen, Michael J.; Palotie, Aarno; Pato, Carlos N.; Petryshen, Tracey L.; Posthuma, Danielle; Riley, Brien P.; Rujescu, Dan; Sham, Pak C.; Sklar, Pamela; Clair, David St; Weinberger, Daniel R.; Wendland, Jens R.; Werge, Thomas; Daly, Mark J.; Sullivan, Patrick F.; O'Donovan, Michael C.

In: Nature communications, Vol. 8, 14774, 21.03.2017.

Research output: Contribution to journalArticle

McLaughlin, RL, Schijven, D, Van Rheenen, W, Van Eijk, KR, O'Brien, M, Kahn, RS, Ophoff, RA, Goris, A, Bradley, DG, Al-Chalabi, A, Van Den Berg, LH, Luykx, JJ, Hardiman, O, Veldink, JH, Shatunov, A, Dekker, AM, Diekstra, FP, Pulit, SL, Van Der Spek, RAA, Van Doormaal, PTC, Sproviero, W, Jones, AR, Nicholson, GA, Rowe, DB, Pamphlett, R, Kiernan, MC, Bauer, D, Kahlke, T, Williams, K, Eftimov, F, Fogh, I, Ticozzi, N, Lin, K, Millecamps, S, Salachas, F, Meininger, V, Carvalho, MD, Pinto, S, Mora, JS, Rojas-Garcyá, R, Polak, M, Chandran, S, Colville, S, Swingler, R, Morrison, KE, Shaw, PJ, Hardy, J, Orrell, RW, Pittman, A, Sidle, K, Fratta, P, Malaspina, A, Petri, S, Abdulla, S, Drepper, C, Sendtner, M, Meyer, T, Wiedau-Pazos, M, Lomen-Hoerth, C, Deerlin, VMV, Trojanowski, JQ, Elman, L, McCluskey, L, Basak, N, Meitinger, T, Lichtner, P, Blagojevic-Radivojkov, M, Andres, CR, Maurel, C, Bensimon, G, Landwehrmeyer, B, Brice, A, Payan, CAM, Saker-Delye, S, Durr, A, Wood, N, Tittmann, L, Lieb, W, Franke, A, Rietschel, M, Cichon, S, Nothen, MM, Amouyel, P, Tzourio, C, Dartigues, JF, Uitterlinden, AG, Rivadeneira, F, Estrada, K, Hofman, A, Curtis, C, Derkooi, AJV, De Visser, M, Weber, M, Shaw, CE, Smith, BN, Pansarasa, O, Cereda, C, Bo, RD, Comi, GP, D'Alfonso, S, Bertolin, C, Soraru, G, Mazzini, L, Pensato, V, Gellera, C, Tiloca, C, Ratti, A, Calvo, A, Moglia, C, Brunetti, M, Arcuti, S, Capozzo, R, Zecca, C, Lunetta, C, Penco, S, Riva, N, Padovani, A, Filosto, M, Blair, I, Nigel Leigh, P, Casale, F, Chio, A, Beghi, E, Pupillo, E, Tortelli, R, Logroscino, G, Powell, J, Ludolph, AC, Weishaupt, JH, Robberecht, W, Damme, PV, Brown, RH, Glass, J, Landers, JE, Andersen, PM, Corcia, P, Vourc'H, P, Silani, V, Es, MAV, Pasterkamp, RJ, Lewis, CM, Breen, G, Ripke, S, Neale, BM, Corvin, A, Walters, JTR, Farh, KH, Holmans, PA, Lee, P, Bulik-Sullivan, B, Collier, DA, Huang, H, Pers, TH, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, SA, Begemann, M, Belliveau, RA, Bene, J, Bergen, SE, Bevilacqua, E, Bigdeli, TB, Black, DW, Bruggeman, R, Buccola, NG, Buckner, RL, Byerley, W, Cahn, W, Cai, G, Campion, D, Cantor, RM, Carr, VJ, Carrera, N, Catts, SV, Chambert, KD, Chan, RCK, Chan, RYL, Chen, EYH, Cheng, W, Cheung, EFC, Chong, SA, Cloninger, CR, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, JJ, Curtis, D, Davidson, M, Davis, KL, Degenhardt, F, Favero, JD, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, AH, Farrell, MS, Frank, J, Franke, L, Freedman, R, Freimer, NB, Friedl, M, Friedman, JI, Fromer, M, Genovese, G, Georgieva, L, Giegling, I, Giusti-Rodrýguez, P, Godard, S, Goldstein, JI, Golimbet, V, Gopal, S, Gratten, J, De Haan, L, Hammer, C, Hamshere, ML, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, AM, Henskens, FA, Herms, S, Hirschhorn, JN, Hoffmann, P, Hofman, A, Hollegaard, MV, Hougaard, DM, Ikeda, M, Joa, I, Julia, A, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Keller, MC, Kennedy, JL, Khrunin, A, Kim, Y, Klovins, J, Knowles, JA, Konte, B, Kucinskas, V, Kucinskiene, ZA, Kuzelova-Ptackova, H, Kahler, AK, Laurent, C, Lee, J, Hong Lee, S, Legge, SE, Lerer, B, Li, M, Li, T, Liang, KY, Lieberman, J, Limborska, S, Loughland, CM, Lubinski, J, Lonnqvist, J, MacEk, M, Magnusson, PKE, Maher, BS, Maier, W, Mallet, J, Marsal, S, Mattheisen, M, Mattingsdal, M, McCarley, RW, McDonald, C, McIntosh, AM, Meier, S, Meijer, CJ, Melegh, B, Melle, I, Mesholam-Gately, RI, Metspalu, A, Michie, PT, Milani, L, Milanova, V, Mokrab, Y, Morris, DW, Mors, O, Murphy, KC, Murray, RM, Myin-Germeys, I, Muller-Myhsok, B, Nelis, M, Nenadic, I, Nertney, DA, Nestadt, G, Nicodemus, KK, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, Anthony O'Neill, F, Oh, SY, Olincy, A, Olsen, L, Vanos, J, Pantelis, C, Papadimitriou, GN, Papiol, S, Parkhomenko, E, Pato, MT, Paunio, T, Pejovic-Milovancevic, M, Perkins, DO, Pietilainen, O, Pimm, J, Pocklington, AJ, Price, A, Pulver, AE, Purcell, SM, Quested, D, Rasmussen, HB, Reichenberg, A, Reimers, MA, Richards, AL, Roffman, JL, Roussos, P, Ruderfer, DM, Salomaa, V, Sanders, AR, Schall, U, Schubert, CR, Schulze, TG, Schwab, SG, Scolnick, EM, Scott, RJ, Seidman, LJ, Shi, J, Sigurdsson, E, Silagadze, T, Silverman, JM, Sim, K, Slominsky, P, Smoller, JW, So, HC, Spencer, CCA, Stah, EA, Stefansson, H, Steinberg, S, Stogmann, E, Straub, RE, Strengman, E, Strohmaier, J, Scott Stroup, T, Subramaniam, M, Suvisaari, J, Svrakic, DM, Szatkiewicz, JP, Söderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, BT, Weiser, M, Wildenauer, DB, Williams, NM, Williams, S, Witt, SH, Wolen, A, Wong, EHM, Wormley, BK, Xi, HS, Zai, CC, Zheng, X, Zimprich, F, Wray, NR, Stefansson, K, Visscher, PM, Adolfsson, R, Andreassen, OA, Blackwood, DHR, Bramon, E, Buxbaum, JD, Børglum, AD, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, PV, Gil, M, Gurling, H, Hultman, CM, Iwata, N, Jablensky, AV, Jonsson, EG, Kendler, KS, Kirov, G, Knight, J, Lencz, T, Levinson, DF, Li, QS, Liu, J, Malhotra, AK, McCarrol, SA, McQuillin, A, Moran, JL, Mortensen, PB, Mowry, BJ, Owen, MJ, Palotie, A, Pato, CN, Petryshen, TL, Posthuma, D, Riley, BP, Rujescu, D, Sham, PC, Sklar, P, Clair, DS, Weinberger, DR, Wendland, JR, Werge, T, Daly, MJ, Sullivan, PF & O'Donovan, MC 2017, 'Genetic correlation between amyotrophic lateral sclerosis and schizophrenia', Nature communications, vol. 8, 14774. https://doi.org/10.1038/ncomms14774
McLaughlin RL, Schijven D, Van Rheenen W, Van Eijk KR, O'Brien M, Kahn RS et al. Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. Nature communications. 2017 Mar 21;8. 14774. https://doi.org/10.1038/ncomms14774
McLaughlin, Russell L. ; Schijven, Dick ; Van Rheenen, Wouter ; Van Eijk, Kristel R. ; O'Brien, Margaret ; Kahn, René S. ; Ophoff, Roel A. ; Goris, An ; Bradley, Daniel G. ; Al-Chalabi, Ammar ; Van Den Berg, Leonard H. ; Luykx, Jurjen J. ; Hardiman, Orla ; Veldink, Jan H. ; Shatunov, Aleksey ; Dekker, Annelot M. ; Diekstra, Frank P. ; Pulit, Sara L. ; Van Der Spek, Rick A.A. ; Van Doormaal, Perry T.C. ; Sproviero, William ; Jones, Ashley R. ; Nicholson, Garth A. ; Rowe, Dominic B. ; Pamphlett, Roger ; Kiernan, Matthew C. ; Bauer, Denis ; Kahlke, Tim ; Williams, Kelly ; Eftimov, Filip ; Fogh, Isabella ; Ticozzi, Nicola ; Lin, Kuang ; Millecamps, Stephanie ; Salachas, Francois ; Meininger, Vincent ; Carvalho, Mamede De ; Pinto, Susana ; Mora, Jesus S. ; Rojas-Garcyá, Ricardo ; Polak, Meraida ; Chandran, Siddharthan ; Colville, Shuna ; Swingler, Robert ; Morrison, Karen E. ; Shaw, Pamela J. ; Hardy, John ; Orrell, Richard W. ; Pittman, Alan ; Sidle, Katie ; Fratta, Pietro ; Malaspina, Andrea ; Petri, Susanne ; Abdulla, Susanna ; Drepper, Carsten ; Sendtner, Michael ; Meyer, Thomas ; Wiedau-Pazos, Martina ; Lomen-Hoerth, Catherine ; Deerlin, Vivianna M.Van ; Trojanowski, John Q. ; Elman, Lauren ; McCluskey, Leo ; Basak, Nazli ; Meitinger, Thomas ; Lichtner, Peter ; Blagojevic-Radivojkov, Milena ; Andres, Christian R. ; Maurel, Cindy ; Bensimon, Gilbert ; Landwehrmeyer, Bernhard ; Brice, Alexis ; Payan, Christine A.M. ; Saker-Delye, Safa ; Durr, Alexandra ; Wood, Nicholas ; Tittmann, Lukas ; Lieb, Wolfgang ; Franke, Andre ; Rietschel, Marcella ; Cichon, Sven ; Nothen, Markus M. ; Amouyel, Philippe ; Tzourio, Christophe ; Dartigues, Jean Francois ; Uitterlinden, Andre G. ; Rivadeneira, Fernando ; Estrada, Karol ; Hofman, Albert ; Curtis, Charles ; Derkooi, Anneke J.Van ; De Visser, Marianne ; Weber, Markus ; Shaw, Christopher E. ; Smith, Bradley N. ; Pansarasa, Orietta ; Cereda, Cristina ; Bo, Roberto Del ; Comi, Giacomo P. ; D'Alfonso, Sandra ; Bertolin, Cinzia ; Soraru, Gianni ; Mazzini, Letizia ; Pensato, Viviana ; Gellera, Cinzia ; Tiloca, Cinzia ; Ratti, Antonia ; Calvo, Andrea ; Moglia, Cristina ; Brunetti, Maura ; Arcuti, Simon ; Capozzo, Rosa ; Zecca, Chiara ; Lunetta, Christian ; Penco, Silvana ; Riva, Nilo ; Padovani, Alessandro ; Filosto, Massimiliano ; Blair, Ian ; Nigel Leigh, P. ; Casale, Federico ; Chio, Adriano ; Beghi, Ettore ; Pupillo, Elisabetta ; Tortelli, Rosanna ; Logroscino, Giancarlo ; Powell, John ; Ludolph, Albert C. ; Weishaupt, Jochen H. ; Robberecht, Wim ; Damme, Philip Van ; Brown, Robert H. ; Glass, Jonathan ; Landers, John E. ; Andersen, Peter M. ; Corcia, Philippe ; Vourc'H, Patrick ; Silani, Vincenzo ; Es, Michael A.Van ; Pasterkamp, R. Jeroen ; Lewis, Cathryn M. ; Breen, Gerome ; Ripke, Stephan ; Neale, Benjamin M. ; Corvin, Aiden ; Walters, James T.R. ; Farh, Kai How ; Holmans, Peter A. ; Lee, Phil ; Bulik-Sullivan, Brendan ; Collier, David A. ; Huang, Hailiang ; Pers, Tune H. ; Agartz, Ingrid ; Agerbo, Esben ; Albus, Margot ; Alexander, Madeline ; Amin, Farooq ; Bacanu, Silviu A. ; Begemann, Martin ; Belliveau, Richard A. ; Bene, Judit ; Bergen, Sarah E. ; Bevilacqua, Elizabeth ; Bigdeli, Tim B. ; Black, Donald W. ; Bruggeman, Richard ; Buccola, Nancy G. ; Buckner, Randy L. ; Byerley, William ; Cahn, Wiepke ; Cai, Guiqing ; Campion, Dominique ; Cantor, Rita M. ; Carr, Vaughan J. ; Carrera, Noa ; Catts, Stanley V. ; Chambert, Kimberley D. ; Chan, Raymond C.K. ; Chan, Ronald Y.L. ; Chen, Eric Y.H. ; Cheng, Wei ; Cheung, Eric F.C. ; Chong, Siow Ann ; Cloninger, C. Robert ; Cohen, David ; Cohen, Nadine ; Cormican, Paul ; Craddock, Nick ; Crowley, James J. ; Curtis, David ; Davidson, Michael ; Davis, Kenneth L. ; Degenhardt, Franziska ; Favero, Jurgen Del ; Demontis, Ditte ; Dikeos, Dimitris ; Dinan, Timothy ; Djurovic, Srdjan ; Donohoe, Gary ; Drapeau, Elodie ; Duan, Jubao ; Dudbridge, Frank ; Durmishi, Naser ; Eichhammer, Peter ; Eriksson, Johan ; Escott-Price, Valentina ; Essioux, Laurent ; Fanous, Ayman H. ; Farrell, Martilias S. ; Frank, Josef ; Franke, Lude ; Freedman, Robert ; Freimer, Nelson B. ; Friedl, Marion ; Friedman, Joseph I. ; Fromer, Menachem ; Genovese, Giulio ; Georgieva, Lyudmila ; Giegling, Ina ; Giusti-Rodrýguez, Paola ; Godard, Stephanie ; Goldstein, Jacqueline I. ; Golimbet, Vera ; Gopal, Srihari ; Gratten, Jacob ; De Haan, Lieuwe ; Hammer, Christian ; Hamshere, Marian L. ; Hansen, Mark ; Hansen, Thomas ; Haroutunian, Vahram ; Hartmann, Annette M. ; Henskens, Frans A. ; Herms, Stefan ; Hirschhorn, Joel N. ; Hoffmann, Per ; Hofman, Andrea ; Hollegaard, Mads V. ; Hougaard, David M. ; Ikeda, Masashi ; Joa, Inge ; Julia, Antonio ; Kalaydjieva, Luba ; Karachanak-Yankova, Sena ; Karjalainen, Juha ; Kavanagh, David ; Keller, Matthew C. ; Kennedy, James L. ; Khrunin, Andrey ; Kim, Yunjung ; Klovins, Janis ; Knowles, James A. ; Konte, Bettina ; Kucinskas, Vaidutis ; Kucinskiene, Zita Ausrele ; Kuzelova-Ptackova, Hana ; Kahler, Anna K. ; Laurent, Claudine ; Lee, Jimmy ; Hong Lee, S. ; Legge, Sophie E. ; Lerer, Bernard ; Li, Miaoxin ; Li, Tao ; Liang, Kung Yee ; Lieberman, Jeffrey ; Limborska, Svetlana ; Loughland, Carmel M. ; Lubinski, Jan ; Lonnqvist, Jouko ; MacEk, Milan ; Magnusson, Patrik K.E. ; Maher, Brion S. ; Maier, Wolfgang ; Mallet, Jacques ; Marsal, Sara ; Mattheisen, Manuel ; Mattingsdal, Morten ; McCarley, Robert W. ; McDonald, Colm ; McIntosh, Andrew M. ; Meier, Sandra ; Meijer, Carin J. ; Melegh, Bela ; Melle, Ingrid ; Mesholam-Gately, Raquelle I. ; Metspalu, Andres ; Michie, Patricia T. ; Milani, Lili ; Milanova, Vihra ; Mokrab, Younes ; Morris, Derek W. ; Mors, Ole ; Murphy, Kieran C. ; Murray, Robin M. ; Myin-Germeys, Inez ; Muller-Myhsok, Bertram ; Nelis, Mari ; Nenadic, Igor ; Nertney, Deborah A. ; Nestadt, Gerald ; Nicodemus, Kristin K. ; Nikitina-Zake, Liene ; Nisenbaum, Laura ; Nordin, Annelie ; O'Callaghan, Eadbhard ; O'Dushlaine, Colm ; Anthony O'Neill, F. ; Oh, Sang Yun ; Olincy, Ann ; Olsen, Line ; Vanos, Jim ; Pantelis, Christos ; Papadimitriou, George N. ; Papiol, Sergi ; Parkhomenko, Elena ; Pato, Michele T. ; Paunio, Tiina ; Pejovic-Milovancevic, Milica ; Perkins, Diana O. ; Pietilainen, Olli ; Pimm, Jonathan ; Pocklington, Andrew J. ; Price, Alkes ; Pulver, Ann E. ; Purcell, Shaun M. ; Quested, Digby ; Rasmussen, Henrik B. ; Reichenberg, Abraham ; Reimers, Mark A. ; Richards, Alexander L. ; Roffman, Joshua L. ; Roussos, Panos ; Ruderfer, Douglas M. ; Salomaa, Veikko ; Sanders, Alan R. ; Schall, Ulrich ; Schubert, Christian R. ; Schulze, Thomas G. ; Schwab, Sibylle G. ; Scolnick, Edward M. ; Scott, Rodney J. ; Seidman, Larry J. ; Shi, Jianxin ; Sigurdsson, Engilbert ; Silagadze, Teimuraz ; Silverman, Jeremy M. ; Sim, Kang ; Slominsky, Petr ; Smoller, Jordan W. ; So, Hon Cheong ; Spencer, Chris C.A. ; Stah, Eli A. ; Stefansson, Hreinn ; Steinberg, Stacy ; Stogmann, Elisabeth ; Straub, Richard E. ; Strengman, Eric ; Strohmaier, Jana ; Scott Stroup, T. ; Subramaniam, Mythily ; Suvisaari, Jaana ; Svrakic, Dragan M. ; Szatkiewicz, Jin P. ; Söderman, Erik ; Thirumalai, Srinivas ; Toncheva, Draga ; Tosato, Sarah ; Veijola, Juha ; Waddington, John ; Walsh, Dermot ; Wang, Dai ; Wang, Qiang ; Webb, Bradley T. ; Weiser, Mark ; Wildenauer, Dieter B. ; Williams, Nigel M. ; Williams, Stephanie ; Witt, Stephanie H. ; Wolen, Aaron ; Wong, Emily H.M. ; Wormley, Brandon K. ; Xi, Hualin Simon ; Zai, Clement C. ; Zheng, Xuebin ; Zimprich, Fritz ; Wray, Naomi R. ; Stefansson, Kari ; Visscher, Peter M. ; Adolfsson, Rolf ; Andreassen, Ole A. ; Blackwood, Douglas H.R. ; Bramon, Elvira ; Buxbaum, Joseph D. ; Børglum, Anders D. ; Darvasi, Ariel ; Domenici, Enrico ; Ehrenreich, Hannelore ; Esko, Tonu ; Gejman, Pablo V. ; Gil, Michael ; Gurling, Hugh ; Hultman, Christina M. ; Iwata, Nakao ; Jablensky, Assen V. ; Jonsson, Erik G. ; Kendler, Kenneth S. ; Kirov, George ; Knight, Jo ; Lencz, Todd ; Levinson, Douglas F. ; Li, Qingqin S. ; Liu, Jianjun ; Malhotra, Anil K. ; McCarrol, Steven A. ; McQuillin, Andrew ; Moran, Jennifer L. ; Mortensen, Preben B. ; Mowry, Bryan J. ; Owen, Michael J. ; Palotie, Aarno ; Pato, Carlos N. ; Petryshen, Tracey L. ; Posthuma, Danielle ; Riley, Brien P. ; Rujescu, Dan ; Sham, Pak C. ; Sklar, Pamela ; Clair, David St ; Weinberger, Daniel R. ; Wendland, Jens R. ; Werge, Thomas ; Daly, Mark J. ; Sullivan, Patrick F. ; O'Donovan, Michael C. / Genetic correlation between amyotrophic lateral sclerosis and schizophrenia. In: Nature communications. 2017 ; Vol. 8.
@article{25bb8b779cd94b0583ee7662da360384,
title = "Genetic correlation between amyotrophic lateral sclerosis and schizophrenia",
abstract = "We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3{\%} (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12{\%} of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.",
author = "McLaughlin, {Russell L.} and Dick Schijven and {Van Rheenen}, Wouter and {Van Eijk}, {Kristel R.} and Margaret O'Brien and Kahn, {Ren{\'e} S.} and Ophoff, {Roel A.} and An Goris and Bradley, {Daniel G.} and Ammar Al-Chalabi and {Van Den Berg}, {Leonard H.} and Luykx, {Jurjen J.} and Orla Hardiman and Veldink, {Jan H.} and Aleksey Shatunov and Dekker, {Annelot M.} and Diekstra, {Frank P.} and Pulit, {Sara L.} and {Van Der Spek}, {Rick A.A.} and {Van Doormaal}, {Perry T.C.} and William Sproviero and Jones, {Ashley R.} and Nicholson, {Garth A.} and Rowe, {Dominic B.} and Roger Pamphlett and Kiernan, {Matthew C.} and Denis Bauer and Tim Kahlke and Kelly Williams and Filip Eftimov and Isabella Fogh and Nicola Ticozzi and Kuang Lin and Stephanie Millecamps and Francois Salachas and Vincent Meininger and Carvalho, {Mamede De} and Susana Pinto and Mora, {Jesus S.} and Ricardo Rojas-Garcy{\'a} and Meraida Polak and Siddharthan Chandran and Shuna Colville and Robert Swingler and Morrison, {Karen E.} and Shaw, {Pamela J.} and John Hardy and Orrell, {Richard W.} and Alan Pittman and Katie Sidle and Pietro Fratta and Andrea Malaspina and Susanne Petri and Susanna Abdulla and Carsten Drepper and Michael Sendtner and Thomas Meyer and Martina Wiedau-Pazos and Catherine Lomen-Hoerth and Deerlin, {Vivianna M.Van} and Trojanowski, {John Q.} and Lauren Elman and Leo McCluskey and Nazli Basak and Thomas Meitinger and Peter Lichtner and Milena Blagojevic-Radivojkov and Andres, {Christian R.} and Cindy Maurel and Gilbert Bensimon and Bernhard Landwehrmeyer and Alexis Brice and Payan, {Christine A.M.} and Safa Saker-Delye and Alexandra Durr and Nicholas Wood and Lukas Tittmann and Wolfgang Lieb and Andre Franke and Marcella Rietschel and Sven Cichon and Nothen, {Markus M.} and Philippe Amouyel and Christophe Tzourio and Dartigues, {Jean Francois} and Uitterlinden, {Andre G.} and Fernando Rivadeneira and Karol Estrada and Albert Hofman and Charles Curtis and Derkooi, {Anneke J.Van} and {De Visser}, Marianne and Markus Weber and Shaw, {Christopher E.} and Smith, {Bradley N.} and Orietta Pansarasa and Cristina Cereda and Bo, {Roberto Del} and Comi, {Giacomo P.} and Sandra D'Alfonso and Cinzia Bertolin and Gianni Soraru and Letizia Mazzini and Viviana Pensato and Cinzia Gellera and Cinzia Tiloca and Antonia Ratti and Andrea Calvo and Cristina Moglia and Maura Brunetti and Simon Arcuti and Rosa Capozzo and Chiara Zecca and Christian Lunetta and Silvana Penco and Nilo Riva and Alessandro Padovani and Massimiliano Filosto and Ian Blair and {Nigel Leigh}, P. and Federico Casale and Adriano Chio and Ettore Beghi and Elisabetta Pupillo and Rosanna Tortelli and Giancarlo Logroscino and John Powell and Ludolph, {Albert C.} and Weishaupt, {Jochen H.} and Wim Robberecht and Damme, {Philip Van} and Brown, {Robert H.} and Jonathan Glass and Landers, {John E.} and Andersen, {Peter M.} and Philippe Corcia and Patrick Vourc'H and Vincenzo Silani and Es, {Michael A.Van} and Pasterkamp, {R. Jeroen} and Lewis, {Cathryn M.} and Gerome Breen and Stephan Ripke and Neale, {Benjamin M.} and Aiden Corvin and Walters, {James T.R.} and Farh, {Kai How} and Holmans, {Peter A.} and Phil Lee and Brendan Bulik-Sullivan and Collier, {David A.} and Hailiang Huang and Pers, {Tune H.} and Ingrid Agartz and Esben Agerbo and Margot Albus and Madeline Alexander and Farooq Amin and Bacanu, {Silviu A.} and Martin Begemann and Belliveau, {Richard A.} and Judit Bene and Bergen, {Sarah E.} and Elizabeth Bevilacqua and Bigdeli, {Tim B.} and Black, {Donald W.} and Richard Bruggeman and Buccola, {Nancy G.} and Buckner, {Randy L.} and William Byerley and Wiepke Cahn and Guiqing Cai and Dominique Campion and Cantor, {Rita M.} and Carr, {Vaughan J.} and Noa Carrera and Catts, {Stanley V.} and Chambert, {Kimberley D.} and Chan, {Raymond C.K.} and Chan, {Ronald Y.L.} and Chen, {Eric Y.H.} and Wei Cheng and Cheung, {Eric F.C.} and Chong, {Siow Ann} and Cloninger, {C. Robert} and David Cohen and Nadine Cohen and Paul Cormican and Nick Craddock and Crowley, {James J.} and David Curtis and Michael Davidson and Davis, {Kenneth L.} and Franziska Degenhardt and Favero, {Jurgen Del} and Ditte Demontis and Dimitris Dikeos and Timothy Dinan and Srdjan Djurovic and Gary Donohoe and Elodie Drapeau and Jubao Duan and Frank Dudbridge and Naser Durmishi and Peter Eichhammer and Johan Eriksson and Valentina Escott-Price and Laurent Essioux and Fanous, {Ayman H.} and Farrell, {Martilias S.} and Josef Frank and Lude Franke and Robert Freedman and Freimer, {Nelson B.} and Marion Friedl and Friedman, {Joseph I.} and Menachem Fromer and Giulio Genovese and Lyudmila Georgieva and Ina Giegling and Paola Giusti-Rodr{\'y}guez and Stephanie Godard and Goldstein, {Jacqueline I.} and Vera Golimbet and Srihari Gopal and Jacob Gratten and {De Haan}, Lieuwe and Christian Hammer and Hamshere, {Marian L.} and Mark Hansen and Thomas Hansen and Vahram Haroutunian and Hartmann, {Annette M.} and Henskens, {Frans A.} and Stefan Herms and Hirschhorn, {Joel N.} and Per Hoffmann and Andrea Hofman and Hollegaard, {Mads V.} and Hougaard, {David M.} and Masashi Ikeda and Inge Joa and Antonio Julia and Luba Kalaydjieva and Sena Karachanak-Yankova and Juha Karjalainen and David Kavanagh and Keller, {Matthew C.} and Kennedy, {James L.} and Andrey Khrunin and Yunjung Kim and Janis Klovins and Knowles, {James A.} and Bettina Konte and Vaidutis Kucinskas and Kucinskiene, {Zita Ausrele} and Hana Kuzelova-Ptackova and Kahler, {Anna K.} and Claudine Laurent and Jimmy Lee and {Hong Lee}, S. and Legge, {Sophie E.} and Bernard Lerer and Miaoxin Li and Tao Li and Liang, {Kung Yee} and Jeffrey Lieberman and Svetlana Limborska and Loughland, {Carmel M.} and Jan Lubinski and Jouko Lonnqvist and Milan MacEk and Magnusson, {Patrik K.E.} and Maher, {Brion S.} and Wolfgang Maier and Jacques Mallet and Sara Marsal and Manuel Mattheisen and Morten Mattingsdal and McCarley, {Robert W.} and Colm McDonald and McIntosh, {Andrew M.} and Sandra Meier and Meijer, {Carin J.} and Bela Melegh and Ingrid Melle and Mesholam-Gately, {Raquelle I.} and Andres Metspalu and Michie, {Patricia T.} and Lili Milani and Vihra Milanova and Younes Mokrab and Morris, {Derek W.} and Ole Mors and Murphy, {Kieran C.} and Murray, {Robin M.} and Inez Myin-Germeys and Bertram Muller-Myhsok and Mari Nelis and Igor Nenadic and Nertney, {Deborah A.} and Gerald Nestadt and Nicodemus, {Kristin K.} and Liene Nikitina-Zake and Laura Nisenbaum and Annelie Nordin and Eadbhard O'Callaghan and Colm O'Dushlaine and {Anthony O'Neill}, F. and Oh, {Sang Yun} and Ann Olincy and Line Olsen and Jim Vanos and Christos Pantelis and Papadimitriou, {George N.} and Sergi Papiol and Elena Parkhomenko and Pato, {Michele T.} and Tiina Paunio and Milica Pejovic-Milovancevic and Perkins, {Diana O.} and Olli Pietilainen and Jonathan Pimm and Pocklington, {Andrew J.} and Alkes Price and Pulver, {Ann E.} and Purcell, {Shaun M.} and Digby Quested and Rasmussen, {Henrik B.} and Abraham Reichenberg and Reimers, {Mark A.} and Richards, {Alexander L.} and Roffman, {Joshua L.} and Panos Roussos and Ruderfer, {Douglas M.} and Veikko Salomaa and Sanders, {Alan R.} and Ulrich Schall and Schubert, {Christian R.} and Schulze, {Thomas G.} and Schwab, {Sibylle G.} and Scolnick, {Edward M.} and Scott, {Rodney J.} and Seidman, {Larry J.} and Jianxin Shi and Engilbert Sigurdsson and Teimuraz Silagadze and Silverman, {Jeremy M.} and Kang Sim and Petr Slominsky and Smoller, {Jordan W.} and So, {Hon Cheong} and Spencer, {Chris C.A.} and Stah, {Eli A.} and Hreinn Stefansson and Stacy Steinberg and Elisabeth Stogmann and Straub, {Richard E.} and Eric Strengman and Jana Strohmaier and {Scott Stroup}, T. and Mythily Subramaniam and Jaana Suvisaari and Svrakic, {Dragan M.} and Szatkiewicz, {Jin P.} and Erik S{\"o}derman and Srinivas Thirumalai and Draga Toncheva and Sarah Tosato and Juha Veijola and John Waddington and Dermot Walsh and Dai Wang and Qiang Wang and Webb, {Bradley T.} and Mark Weiser and Wildenauer, {Dieter B.} and Williams, {Nigel M.} and Stephanie Williams and Witt, {Stephanie H.} and Aaron Wolen and Wong, {Emily H.M.} and Wormley, {Brandon K.} and Xi, {Hualin Simon} and Zai, {Clement C.} and Xuebin Zheng and Fritz Zimprich and Wray, {Naomi R.} and Kari Stefansson and Visscher, {Peter M.} and Rolf Adolfsson and Andreassen, {Ole A.} and Blackwood, {Douglas H.R.} and Elvira Bramon and Buxbaum, {Joseph D.} and B{\o}rglum, {Anders D.} and Ariel Darvasi and Enrico Domenici and Hannelore Ehrenreich and Tonu Esko and Gejman, {Pablo V.} and Michael Gil and Hugh Gurling and Hultman, {Christina M.} and Nakao Iwata and Jablensky, {Assen V.} and Jonsson, {Erik G.} and Kendler, {Kenneth S.} and George Kirov and Jo Knight and Todd Lencz and Levinson, {Douglas F.} and Li, {Qingqin S.} and Jianjun Liu and Malhotra, {Anil K.} and McCarrol, {Steven A.} and Andrew McQuillin and Moran, {Jennifer L.} and Mortensen, {Preben B.} and Mowry, {Bryan J.} and Owen, {Michael J.} and Aarno Palotie and Pato, {Carlos N.} and Petryshen, {Tracey L.} and Danielle Posthuma and Riley, {Brien P.} and Dan Rujescu and Sham, {Pak C.} and Pamela Sklar and Clair, {David St} and Weinberger, {Daniel R.} and Wendland, {Jens R.} and Thomas Werge and Daly, {Mark J.} and Sullivan, {Patrick F.} and O'Donovan, {Michael C.}",
year = "2017",
month = "3",
day = "21",
doi = "10.1038/ncomms14774",
language = "English (US)",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

AU - McLaughlin, Russell L.

AU - Schijven, Dick

AU - Van Rheenen, Wouter

AU - Van Eijk, Kristel R.

AU - O'Brien, Margaret

AU - Kahn, René S.

AU - Ophoff, Roel A.

AU - Goris, An

AU - Bradley, Daniel G.

AU - Al-Chalabi, Ammar

AU - Van Den Berg, Leonard H.

AU - Luykx, Jurjen J.

AU - Hardiman, Orla

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AU - Shatunov, Aleksey

AU - Dekker, Annelot M.

AU - Diekstra, Frank P.

AU - Pulit, Sara L.

AU - Van Der Spek, Rick A.A.

AU - Van Doormaal, Perry T.C.

AU - Sproviero, William

AU - Jones, Ashley R.

AU - Nicholson, Garth A.

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AU - Pamphlett, Roger

AU - Kiernan, Matthew C.

AU - Bauer, Denis

AU - Kahlke, Tim

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AU - Ticozzi, Nicola

AU - Lin, Kuang

AU - Millecamps, Stephanie

AU - Salachas, Francois

AU - Meininger, Vincent

AU - Carvalho, Mamede De

AU - Pinto, Susana

AU - Mora, Jesus S.

AU - Rojas-Garcyá, Ricardo

AU - Polak, Meraida

AU - Chandran, Siddharthan

AU - Colville, Shuna

AU - Swingler, Robert

AU - Morrison, Karen E.

AU - Shaw, Pamela J.

AU - Hardy, John

AU - Orrell, Richard W.

AU - Pittman, Alan

AU - Sidle, Katie

AU - Fratta, Pietro

AU - Malaspina, Andrea

AU - Petri, Susanne

AU - Abdulla, Susanna

AU - Drepper, Carsten

AU - Sendtner, Michael

AU - Meyer, Thomas

AU - Wiedau-Pazos, Martina

AU - Lomen-Hoerth, Catherine

AU - Deerlin, Vivianna M.Van

AU - Trojanowski, John Q.

AU - Elman, Lauren

AU - McCluskey, Leo

AU - Basak, Nazli

AU - Meitinger, Thomas

AU - Lichtner, Peter

AU - Blagojevic-Radivojkov, Milena

AU - Andres, Christian R.

AU - Maurel, Cindy

AU - Bensimon, Gilbert

AU - Landwehrmeyer, Bernhard

AU - Brice, Alexis

AU - Payan, Christine A.M.

AU - Saker-Delye, Safa

AU - Durr, Alexandra

AU - Wood, Nicholas

AU - Tittmann, Lukas

AU - Lieb, Wolfgang

AU - Franke, Andre

AU - Rietschel, Marcella

AU - Cichon, Sven

AU - Nothen, Markus M.

AU - Amouyel, Philippe

AU - Tzourio, Christophe

AU - Dartigues, Jean Francois

AU - Uitterlinden, Andre G.

AU - Rivadeneira, Fernando

AU - Estrada, Karol

AU - Hofman, Albert

AU - Curtis, Charles

AU - Derkooi, Anneke J.Van

AU - De Visser, Marianne

AU - Weber, Markus

AU - Shaw, Christopher E.

AU - Smith, Bradley N.

AU - Pansarasa, Orietta

AU - Cereda, Cristina

AU - Bo, Roberto Del

AU - Comi, Giacomo P.

AU - D'Alfonso, Sandra

AU - Bertolin, Cinzia

AU - Soraru, Gianni

AU - Mazzini, Letizia

AU - Pensato, Viviana

AU - Gellera, Cinzia

AU - Tiloca, Cinzia

AU - Ratti, Antonia

AU - Calvo, Andrea

AU - Moglia, Cristina

AU - Brunetti, Maura

AU - Arcuti, Simon

AU - Capozzo, Rosa

AU - Zecca, Chiara

AU - Lunetta, Christian

AU - Penco, Silvana

AU - Riva, Nilo

AU - Padovani, Alessandro

AU - Filosto, Massimiliano

AU - Blair, Ian

AU - Nigel Leigh, P.

AU - Casale, Federico

AU - Chio, Adriano

AU - Beghi, Ettore

AU - Pupillo, Elisabetta

AU - Tortelli, Rosanna

AU - Logroscino, Giancarlo

AU - Powell, John

AU - Ludolph, Albert C.

AU - Weishaupt, Jochen H.

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AU - Corcia, Philippe

AU - Vourc'H, Patrick

AU - Silani, Vincenzo

AU - Es, Michael A.Van

AU - Pasterkamp, R. Jeroen

AU - Lewis, Cathryn M.

AU - Breen, Gerome

AU - Ripke, Stephan

AU - Neale, Benjamin M.

AU - Corvin, Aiden

AU - Walters, James T.R.

AU - Farh, Kai How

AU - Holmans, Peter A.

AU - Lee, Phil

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AU - Huang, Hailiang

AU - Pers, Tune H.

AU - Agartz, Ingrid

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AU - Albus, Margot

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AU - Begemann, Martin

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AU - Bene, Judit

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AU - Bevilacqua, Elizabeth

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AU - Black, Donald W.

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AU - Cahn, Wiepke

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AU - Chambert, Kimberley D.

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AU - Cheng, Wei

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AU - Cohen, David

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AU - Cormican, Paul

AU - Craddock, Nick

AU - Crowley, James J.

AU - Curtis, David

AU - Davidson, Michael

AU - Davis, Kenneth L.

AU - Degenhardt, Franziska

AU - Favero, Jurgen Del

AU - Demontis, Ditte

AU - Dikeos, Dimitris

AU - Dinan, Timothy

AU - Djurovic, Srdjan

AU - Donohoe, Gary

AU - Drapeau, Elodie

AU - Duan, Jubao

AU - Dudbridge, Frank

AU - Durmishi, Naser

AU - Eichhammer, Peter

AU - Eriksson, Johan

AU - Escott-Price, Valentina

AU - Essioux, Laurent

AU - Fanous, Ayman H.

AU - Farrell, Martilias S.

AU - Frank, Josef

AU - Franke, Lude

AU - Freedman, Robert

AU - Freimer, Nelson B.

AU - Friedl, Marion

AU - Friedman, Joseph I.

AU - Fromer, Menachem

AU - Genovese, Giulio

AU - Georgieva, Lyudmila

AU - Giegling, Ina

AU - Giusti-Rodrýguez, Paola

AU - Godard, Stephanie

AU - Goldstein, Jacqueline I.

AU - Golimbet, Vera

AU - Gopal, Srihari

AU - Gratten, Jacob

AU - De Haan, Lieuwe

AU - Hammer, Christian

AU - Hamshere, Marian L.

AU - Hansen, Mark

AU - Hansen, Thomas

AU - Haroutunian, Vahram

AU - Hartmann, Annette M.

AU - Henskens, Frans A.

AU - Herms, Stefan

AU - Hirschhorn, Joel N.

AU - Hoffmann, Per

AU - Hofman, Andrea

AU - Hollegaard, Mads V.

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AU - Ikeda, Masashi

AU - Joa, Inge

AU - Julia, Antonio

AU - Kalaydjieva, Luba

AU - Karachanak-Yankova, Sena

AU - Karjalainen, Juha

AU - Kavanagh, David

AU - Keller, Matthew C.

AU - Kennedy, James L.

AU - Khrunin, Andrey

AU - Kim, Yunjung

AU - Klovins, Janis

AU - Knowles, James A.

AU - Konte, Bettina

AU - Kucinskas, Vaidutis

AU - Kucinskiene, Zita Ausrele

AU - Kuzelova-Ptackova, Hana

AU - Kahler, Anna K.

AU - Laurent, Claudine

AU - Lee, Jimmy

AU - Hong Lee, S.

AU - Legge, Sophie E.

AU - Lerer, Bernard

AU - Li, Miaoxin

AU - Li, Tao

AU - Liang, Kung Yee

AU - Lieberman, Jeffrey

AU - Limborska, Svetlana

AU - Loughland, Carmel M.

AU - Lubinski, Jan

AU - Lonnqvist, Jouko

AU - MacEk, Milan

AU - Magnusson, Patrik K.E.

AU - Maher, Brion S.

AU - Maier, Wolfgang

AU - Mallet, Jacques

AU - Marsal, Sara

AU - Mattheisen, Manuel

AU - Mattingsdal, Morten

AU - McCarley, Robert W.

AU - McDonald, Colm

AU - McIntosh, Andrew M.

AU - Meier, Sandra

AU - Meijer, Carin J.

AU - Melegh, Bela

AU - Melle, Ingrid

AU - Mesholam-Gately, Raquelle I.

AU - Metspalu, Andres

AU - Michie, Patricia T.

AU - Milani, Lili

AU - Milanova, Vihra

AU - Mokrab, Younes

AU - Morris, Derek W.

AU - Mors, Ole

AU - Murphy, Kieran C.

AU - Murray, Robin M.

AU - Myin-Germeys, Inez

AU - Muller-Myhsok, Bertram

AU - Nelis, Mari

AU - Nenadic, Igor

AU - Nertney, Deborah A.

AU - Nestadt, Gerald

AU - Nicodemus, Kristin K.

AU - Nikitina-Zake, Liene

AU - Nisenbaum, Laura

AU - Nordin, Annelie

AU - O'Callaghan, Eadbhard

AU - O'Dushlaine, Colm

AU - Anthony O'Neill, F.

AU - Oh, Sang Yun

AU - Olincy, Ann

AU - Olsen, Line

AU - Vanos, Jim

AU - Pantelis, Christos

AU - Papadimitriou, George N.

AU - Papiol, Sergi

AU - Parkhomenko, Elena

AU - Pato, Michele T.

AU - Paunio, Tiina

AU - Pejovic-Milovancevic, Milica

AU - Perkins, Diana O.

AU - Pietilainen, Olli

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AU - Bramon, Elvira

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AU - Darvasi, Ariel

AU - Domenici, Enrico

AU - Ehrenreich, Hannelore

AU - Esko, Tonu

AU - Gejman, Pablo V.

AU - Gil, Michael

AU - Gurling, Hugh

AU - Hultman, Christina M.

AU - Iwata, Nakao

AU - Jablensky, Assen V.

AU - Jonsson, Erik G.

AU - Kendler, Kenneth S.

AU - Kirov, George

AU - Knight, Jo

AU - Lencz, Todd

AU - Levinson, Douglas F.

AU - Li, Qingqin S.

AU - Liu, Jianjun

AU - Malhotra, Anil K.

AU - McCarrol, Steven A.

AU - McQuillin, Andrew

AU - Moran, Jennifer L.

AU - Mortensen, Preben B.

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AU - Riley, Brien P.

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AU - Sham, Pak C.

AU - Sklar, Pamela

AU - Clair, David St

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AU - Werge, Thomas

AU - Daly, Mark J.

AU - Sullivan, Patrick F.

AU - O'Donovan, Michael C.

PY - 2017/3/21

Y1 - 2017/3/21

N2 - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

AB - We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P=1 × 10-4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10-7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

UR - http://www.scopus.com/inward/record.url?scp=85016060348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85016060348&partnerID=8YFLogxK

U2 - 10.1038/ncomms14774

DO - 10.1038/ncomms14774

M3 - Article

VL - 8

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 14774

ER -