Genetic mapping of a cloned sequence responsible for susceptibility to ectropic murine leukemia viruses

C. A. Kozak, Lorraine Albritton, J. Cunningham

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A mouse cDNA that confers susceptibility to ecotropic murine leukemia viruses following transfection into human EJ cells has been cloned and sequenced. We show that this sequence is likely to be Rec-I, the chromosome 5 locus originally defined by studies with somatic cell hybrids as responsible for virus susceptibility, and provide a specific chromosomal map position for this locus by analysis of an interspecies backcross. This locus maps in the distal region of chromosome 5 and is thus not within the cluster of retrovirus-related genes near the centromere.

Original languageEnglish (US)
Pages (from-to)3119-3121
Number of pages3
JournalJournal of Virology
Volume64
Issue number6
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Murine leukemia virus
Murine Leukemia Viruses
Chromosomes, Human, Pair 5
chromosome mapping
loci
Centromere
Hybrid Cells
Retroviridae
chromosomes
Transfection
Complementary DNA
centromeres
transfection
Viruses
somatic cells
Genes
viruses
mice
genes
cells

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

Cite this

Genetic mapping of a cloned sequence responsible for susceptibility to ectropic murine leukemia viruses. / Kozak, C. A.; Albritton, Lorraine; Cunningham, J.

In: Journal of Virology, Vol. 64, No. 6, 01.01.1990, p. 3119-3121.

Research output: Contribution to journalArticle

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