Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice

G. D. Rosen, C. J. Pung, C. B. Owens, J. Caplow, H. Kim, Khyobeni Mozhui, Lu Lu, Robert Williams

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Natural variation in the absolute and relative size of different parts of the human brain is substantial, with a range that often exceeds a factor of 2. Much of this variation is generated by the cumulative effects of sets of unknown gene variants that modulate the proliferation, growth and death of neurons and glial cells. Discovering and testing the functions of these genes should contribute significantly to our understanding of differences in brain development, behavior and disease susceptibility. We have exploited a large population of genetically well-characterized strains of mice (BXD recombinant inbred strains) to map gene variants that influence the volume of the dorsal striatum (caudate-putamen without nucleus accumbens). We used unbiased methods to estimate volumes bilaterally in a sex-balanced sample taken from the Mouse Brain Library (www.mbl.org). We generated a matched microarray data set to efficiently evaluate candidate genes (www.genenetwork.org). As in humans, volume of the striatum is highly heritable, with greater than twofold differences among strains. We mapped a locus that modulates striatal volume on chromosome (Chr) 6 at 88 ± 5 Mb. We also uncovered an epistatic interaction between loci on Chr 6 and Chr 17 that modulates striatal volume. Using bioinformatic tools and the corresponding expression database, we have identified positional candidates in these quantitative trait locus intervals.

Original languageEnglish (US)
Pages (from-to)296-308
Number of pages13
JournalGenes, Brain and Behavior
Volume8
Issue number3
DOIs
StatePublished - Apr 1 2009

Fingerprint

Corpus Striatum
Chromosomes, Human, Pair 6
Genes
Brain
Chromosomes, Human, Pair 17
Quantitative Trait Loci
Putamen
Disease Susceptibility
Nucleus Accumbens
Computational Biology
Neuroglia
Databases
Neurons
Growth
Population

All Science Journal Classification (ASJC) codes

  • Genetics
  • Neurology
  • Behavioral Neuroscience

Cite this

Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. / Rosen, G. D.; Pung, C. J.; Owens, C. B.; Caplow, J.; Kim, H.; Mozhui, Khyobeni; Lu, Lu; Williams, Robert.

In: Genes, Brain and Behavior, Vol. 8, No. 3, 01.04.2009, p. 296-308.

Research output: Contribution to journalArticle

Rosen, G. D. ; Pung, C. J. ; Owens, C. B. ; Caplow, J. ; Kim, H. ; Mozhui, Khyobeni ; Lu, Lu ; Williams, Robert. / Genetic modulation of striatal volume by loci on Chrs 6 and 17 in BXD recombinant inbred mice. In: Genes, Brain and Behavior. 2009 ; Vol. 8, No. 3. pp. 296-308.
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